慢性乙型肝炎与肌病的关联。
The association of chronic hepatitis B and myopathy.
作者信息
Capasso M, Di Muzio A, Comar M, Robuffo I, Gambi A, Crovella S, Pizzigallo E, Campello C, Uncini A
机构信息
Aging Research Center CeSI , Gabriele d'Annunzio University Foundation Chieti-Pescara and Interuniversitary Institute of Myology, Chieti, Italy.
出版信息
Neurology. 2006 Oct 24;67(8):1467-9. doi: 10.1212/01.wnl.0000240078.47020.5e.
In two patients with chronic hepatitis B and myopathy, muscle biopsy showed necrosis and scarce inflammatory infiltrates. CD8+ cells surrounded some non-necrotic fibers. Hepatitis B virus (HBV) DNA and antigens were found inside intact muscle fibers. Major histocompatibility complex class I antigens were coexpressed with viral antigens. In one patient, symptoms improved during antiviral therapy. HBV can infect muscle fibers and an immune-mediated response to viral antigens may cause muscle injury.
在两名慢性乙型肝炎合并肌病患者中，肌肉活检显示坏死且炎症浸润稀少。CD8 +细胞围绕着一些非坏死纤维。在完整的肌纤维内发现了乙型肝炎病毒（HBV）DNA和抗原。主要组织相容性复合体I类抗原与病毒抗原共表达。在一名患者中，抗病毒治疗期间症状有所改善。HBV可感染肌纤维，对病毒抗原的免疫介导反应可能导致肌肉损伤。
Zotero 插件