Shen W, Punyanitya M, Chen J, Gallagher D, Albu J, Pi-Sunyer X, Lewis C E, Grunfeld C, Heymsfield S B, Heshka S
Obesity Research Center, St Luke's-Roosevelt Hospital and Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA.
Int J Obes (Lond). 2007 May;31(5):763-9. doi: 10.1038/sj.ijo.0803474. Epub 2006 Oct 24.
Visceral adipose tissue (VAT) is widely recognized as conveying the highest health risk in humans among the currently measurable adipose tissue compartments. A recent study indicated that the traditionally measured VAT area at L(4)-L(5) is not the VAT area with the highest correlation with total VAT volume. At present, it is unknown whether the area with the highest correlation is also the most strongly associated with obesity-related health risk.
The study aim was to establish which VAT slice area(s) are most strongly associated with obesity-related health risk indicators.
The subjects were a convenience sample of healthy adults who completed whole-body magnetic resonance imaging (MRI) scans. The correlations, with appropriate adjustments, were examined between individual MRI slice VAT areas and fasting serum/plasma triglycerides (TG), high-density lipoprotein cholesterol (HDL), glucose, insulin and blood pressure.
The sample consisted of 283 healthy men (age (mean+/-s.d.) 41.9+/-15.8 years; BMI, 26.0+/-3.2 kg/m(2); VAT, 2.7+/-1.8 L) and 411 women (age, 48.1+/-18.7 years; BMI 27.0+/-5.4 kg/m(2); VAT, 1.7+/-1.2 L). After adjusting for age, race, menopause status, scan position and specific blood analysis laboratory, VAT area at L(4)-L(5) had lower correlations with most metabolic risk factors including serum/plasma TG, HDL, glucose, insulin and blood pressure than VAT volume in both men and women. The VAT areas 10 and 15 cm above L(4)-L(5) in men had higher or equal correlations with health risk measures than VAT volume. In women, the VAT area 5 cm above or below L(4)-L(5) and total VAT volume had similar correlations with health risk measures.
An appropriately selected single slice VAT area is an equally reliable phenotypic marker of obesity-related health risk as total VAT volume. However, in both men and women the VAT slice area at the traditional L(4)-L(5) level is not the best marker of obesity-related health risk.
在内脏脂肪组织（VAT）是目前可测量的脂肪组织分区中，被广泛认为对人类健康风险最高的。最近一项研究表明，传统测量的L4-L5水平的VAT面积并非与总VAT体积相关性最高的VAT面积。目前尚不清楚相关性最高的区域是否也与肥胖相关健康风险关联最为密切。
本研究旨在确定哪些VAT切片面积与肥胖相关健康风险指标关联最为密切。
研究对象为完成全身磁共振成像（MRI）扫描的健康成年人便利样本。对个体MRI切片VAT面积与空腹血清/血浆甘油三酯（TG）、高密度脂蛋白胆固醇（HDL）、葡萄糖、胰岛素和血压之间的相关性进行了适当调整后进行检查。
样本包括283名健康男性（年龄（均值±标准差）41.9±15.8岁；体重指数，26.0±3.2kg/m²；VAT，2.7±1.8L）和411名女性（年龄，48.1±18.7岁；体重指数27.0±5.4kg/m²；VAT，1.7±1.2L）。在调整年龄、种族、绝经状态、扫描位置和特定血液分析实验室因素后，L4-L5水平的VAT面积与大多数代谢风险因素（包括血清/血浆TG、HDL、葡萄糖、胰岛素和血压）的相关性在男性和女性中均低于VAT体积。男性中L4-L5水平上方10cm和15cm处的VAT面积与健康风险指标的相关性高于或等于VAT体积。在女性中，L4-L5水平上方或下方5cm处的VAT面积与总VAT体积与健康风险指标的相关性相似。
适当选择的单个切片VAT面积与总VAT体积一样，是肥胖相关健康风险同样可靠的表型标志物。然而，在男性和女性中，传统L4-L5水平的VAT切片面积都不是肥胖相关健康风险的最佳标志物。
