Ito M, Barron A L, Olszewski W A, Milgrom F
Proc Soc Exp Biol Med. 1975 Sep;149(4):835-9. doi: 10.3181/00379727-149-38909.
Antibody titers to varicella-zoster (V-Z), herpes simplex (HSV) and vaccinia viruses were determined in sera collected in Buffalo, NY, from patients with multiple sclerosis (MS), patients with other diseases, and normal individuals. The mixed agglutination test employing cell cultures infected with one of the above viruses as a source of antigen was used to determine antibody titers. The geometric mean titer (GMT) for V-Z in 59 MS cases was significantly higher than that observed in patients with other diseases and in normal individuals. The GMT for vaccinia was also higher in MS patients but the difference was not as great as for V-Z. No difference was observed in the titer of antibodies for HSV. Similar results were obtained for 51 MS patients compared to healthy controls matched for sex and age. Higher antibody titers for V-Z and HSV were observed in cerebrospinal fluids from MS cases than in those from non-MS CNS patients in Baltimore, MD. Antibodies to V-Z, HSV and vaccinia were detected in washing fluids from brain homogenates of MS cases.
在纽约州布法罗市采集的血清中，测定了多发性硬化症（MS）患者、患有其他疾病的患者以及正常个体针对水痘 - 带状疱疹病毒（V - Z）、单纯疱疹病毒（HSV）和牛痘病毒的抗体滴度。采用以感染上述病毒之一的细胞培养物作为抗原来源的混合凝集试验来测定抗体滴度。59例MS患者中V - Z的几何平均滴度（GMT）显著高于患有其他疾病的患者和正常个体中观察到的滴度。MS患者中牛痘的GMT也较高，但差异不如V - Z那么大。HSV抗体滴度未观察到差异。与按性别和年龄匹配的健康对照相比，51例MS患者也得到了类似结果。在马里兰州巴尔的摩市，MS病例脑脊液中V - Z和HSV的抗体滴度高于非MS中枢神经系统疾病患者脑脊液中的抗体滴度。在MS病例脑匀浆的洗涤液中检测到了针对V - Z、HSV和牛痘的抗体。
