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对于报告的视觉功能改善预测概率较低的老年患者,白内障手术是否具有成本效益?

Is cataract surgery cost-effective among older patients with a low predicted probability for improvement in reported visual functioning?

作者信息

Naeim Arash, Keeler Emmett B, Gutierrez Peter R, Wilson M Roy, Reuben David, Mangione Carol M

机构信息

Division of Hematology-Oncology, UCLA Department of Medicine, Los Angeles, California 90095-1687, USA.

出版信息

Med Care. 2006 Nov;44(11):982-9. doi: 10.1097/01.mlr.0000228216.18270.3e.

Abstract

INTRODUCTION

Although cataract surgery has been demonstrated to be effective and cost-effective, 5% to 20% of patients do not benefit functionally from the procedure. This study examines the cost-effectiveness of cataract surgery versus watchful waiting in a subgroup of patients who had less than a 30% predicted probability of reporting improvements in visual function after surgery.

METHODS

Randomized trial (first eye surgery vs. watchful waiting) of 250 patients who based on a cataract surgery index (CSI) were felt to have less than a 30% probability of reporting improvements in visual functioning after surgery. Cost was estimated using monthly resource utilization surveys and Medicare billing and payment data. Effectiveness was evaluated at 6 months using the Activities of Daily Vision Scale (ADVS) and the Health Utilities Index, Mark 3 (HUI3).

RESULTS

In terms of overall utility, the incremental cost-effectiveness of surgery was Dollars 38,288/QALY. In the subgroup of patients with a CSI score > 11 (< 20% probability of improvement), the cost-effectiveness of cataract surgery was Dollars 53,500/QALY. Sensitivity analysis demonstrated that often this population of patients may not derive a utility benefit with surgery.

CONCLUSION

Cataract surgery is cost-effective even in a subpopulation of patient with a lower, < 30%, predicted probability of reporting improved visual functioning after surgery. There may be a subgroup of patients, CSI > 11, for whom a strategy of watchful waiting may be equally effective and considerably less expensive.

摘要

引言

尽管白内障手术已被证明是有效且具有成本效益的,但仍有5%至20%的患者未能从该手术中获得功能上的益处。本研究探讨了在一组预计术后视觉功能改善概率低于30%的患者中,白内障手术与观察等待相比的成本效益。

方法

对250名患者进行随机试验(第一眼手术与观察等待),这些患者基于白内障手术指数(CSI)被认为术后视觉功能改善的概率低于30%。使用月度资源利用调查以及医疗保险计费和支付数据估算成本。在6个月时使用日常视觉活动量表(ADVS)和健康效用指数Mark 3(HUI3)评估有效性。

结果

就总体效用而言,手术的增量成本效益为38,288美元/质量调整生命年。在CSI评分>11(改善概率<20%)的患者亚组中,白内障手术的成本效益为53,500美元/质量调整生命年。敏感性分析表明,这类患者群体往往无法从手术中获得效用益处。

结论

即使在预计术后视觉功能改善概率较低(<30%)的患者亚组中,白内障手术仍具有成本效益。可能存在一个患者亚组,即CSI>11,对于他们来说,观察等待策略可能同样有效且成本低得多。

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