被免疫抵抗坏死性肠炎的肉鸡识别的产气荚膜梭菌抗原。
Clostridium perfringens antigens recognized by broiler chickens immune to necrotic enteritis.
作者信息
Kulkarni R R, Parreira V R, Sharif S, Prescott J F
机构信息
Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
出版信息
Clin Vaccine Immunol. 2006 Dec;13(12):1358-62. doi: 10.1128/CVI.00292-06. Epub 2006 Oct 25.
Abstract
Little is known about immunity to necrotic enteritis (NE) in chickens. A recent study of broiler chickens showed that protection against NE was associated with infection-immunization with virulent but not with avirulent Clostridium perfringens. In the current study, six secreted antigenic proteins unique to virulent C. perfringens that reacted to serum antibodies from immune birds were identified by mass spectrophotometry; three of these proteins are part of the VirR-VirS regulon.
摘要
关于鸡对坏死性肠炎（NE）的免疫力，目前所知甚少。最近一项针对肉鸡的研究表明，对NE的保护作用与用强毒产气荚膜梭菌进行感染免疫有关，而与无毒产气荚膜梭菌无关。在本研究中，通过质谱分析法鉴定出六种强毒产气荚膜梭菌特有的分泌抗原蛋白，这些蛋白能与免疫鸡的血清抗体发生反应；其中三种蛋白是VirR-VirS调节子的一部分。
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