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被免疫抵抗坏死性肠炎的肉鸡识别的产气荚膜梭菌抗原。

Clostridium perfringens antigens recognized by broiler chickens immune to necrotic enteritis.

作者信息

Kulkarni R R, Parreira V R, Sharif S, Prescott J F

机构信息

Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.

出版信息

Clin Vaccine Immunol. 2006 Dec;13(12):1358-62. doi: 10.1128/CVI.00292-06. Epub 2006 Oct 25.

DOI:10.1128/CVI.00292-06
PMID:17065258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1694445/
Abstract

Little is known about immunity to necrotic enteritis (NE) in chickens. A recent study of broiler chickens showed that protection against NE was associated with infection-immunization with virulent but not with avirulent Clostridium perfringens. In the current study, six secreted antigenic proteins unique to virulent C. perfringens that reacted to serum antibodies from immune birds were identified by mass spectrophotometry; three of these proteins are part of the VirR-VirS regulon.

摘要

关于鸡对坏死性肠炎（NE）的免疫力，目前所知甚少。最近一项针对肉鸡的研究表明，对NE的保护作用与用强毒产气荚膜梭菌进行感染免疫有关，而与无毒产气荚膜梭菌无关。在本研究中，通过质谱分析法鉴定出六种强毒产气荚膜梭菌特有的分泌抗原蛋白，这些蛋白能与免疫鸡的血清抗体发生反应；其中三种蛋白是VirR-VirS调节子的一部分。

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本文引用的文献

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Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens.产气荚膜梭菌的α毒素并非鸡坏死性肠炎中的必需毒力因子。
Infect Immun. 2006 Nov;74(11):6496-500. doi: 10.1128/IAI.00806-06. Epub 2006 Aug 21.
2
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Vet Microbiol. 2006 Mar 10;113(1-2):25-34. doi: 10.1016/j.vetmic.2005.10.015. Epub 2005 Nov 11.
3
Glycolytic enzymes associated with the cell surface of Streptococcus pneumoniae are antigenic in humans and elicit protective immune responses in the mouse.与肺炎链球菌细胞表面相关的糖酵解酶在人类中具有抗原性，并在小鼠中引发保护性免疫反应。
Clin Exp Immunol. 2004 Nov;138(2):290-8. doi: 10.1111/j.1365-2249.2004.02628.x.
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Immunization with the C-Domain of alpha -Toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens.用α-毒素的C结构域进行免疫可预防致死性感染，定位组织损伤，并促进宿主对产气荚膜梭菌攻击的反应。
J Infect Dis. 2004 Aug 15;190(4):767-73. doi: 10.1086/422691. Epub 2004 Jul 19.
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FEMS Microbiol Lett. 2004 Jun 15;235(2):289-95. doi: 10.1016/j.femsle.2004.04.047.
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