Sugimachi K, Tsutsui S, Kitamura K, Morita M, Mori M, Kuwano H
Department of Surgery II, Kyushu University, Fukuoka, Japan.
J Surg Oncol. 1991 Apr;46(4):226-9. doi: 10.1002/jso.2930460404.
An adequate proximal surgical margin is difficult to determine particularly in cases of esophageal carcinoma with surrounding intraepithelial invasion. We report here readily facilitated intraoperative approaches for detection of the exact margin of carcinomatous invasion of the esophagus. The resected specimen of the esophagus is incised longitudinally and placed in a 1% Lugol bath for 2-3 minutes. The normal squamous epithelium includes glycogen that interacts with the iodine of Lugol's solution and the normal epithelium of the esophagus becomes a uniform greenish-brown. A squamous cell carcinoma does not include glycogen, hence is not stained with this solution and a clear identification is feasible. Thus, a carcinomatous infiltration not recognizable in routine examinations becomes macroscopically visible when Lugol's solution is used.
确定足够的近端手术切缘尤其困难，特别是在伴有周围上皮内浸润的食管癌病例中。我们在此报告了便于术中检测食管癌确切浸润边缘的方法。将切除的食管标本纵向切开，置于1%卢戈氏液中浸泡2 - 3分钟。正常鳞状上皮含有糖原，可与卢戈氏液中的碘发生反应，食管的正常上皮会变成均匀的绿褐色。鳞状细胞癌不含糖原，因此不会被该溶液染色，从而可以清晰识别。这样，在常规检查中无法识别的癌浸润在用卢戈氏液处理后在宏观上就变得可见了。
