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本文引用的文献

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Geographic variation in the susceptibilities of invasive isolates of Candida glabrata to seven systemically active antifungal agents: a global assessment from the ARTEMIS Antifungal Surveillance Program conducted in 2001 and 2002.光滑念珠菌侵袭性分离株对七种全身用抗真菌药物敏感性的地域差异：2001年和2002年开展的ARTEMIS抗真菌监测项目的全球评估
J Clin Microbiol. 2004 Jul;42(7):3142-6. doi: 10.1128/JCM.42.7.3142-3146.2004.
2
Determination of fungicidal activities against yeasts and molds: lessons learned from bactericidal testing and the need for standardization.针对酵母和霉菌的杀真菌活性测定：从杀菌测试中吸取的经验教训以及标准化的必要性。
Clin Microbiol Rev. 2004 Apr;17(2):268-80. doi: 10.1128/CMR.17.2.268-280.2004.
3
Combination antifungal therapy.联合抗真菌治疗。
Antimicrob Agents Chemother. 2004 Mar;48(3):693-715. doi: 10.1128/AAC.48.3.693-715.2004.
4
Caspofungin.卡泊芬净
Clin Infect Dis. 2003 Jun 1;36(11):1445-57. doi: 10.1086/375080. Epub 2003 May 19.
5
Efficacy of caspofungin combined with amphotericin B against azole-resistant Candida albicans.卡泊芬净联合两性霉素B治疗对唑类耐药的白色念珠菌的疗效。
J Antimicrob Chemother. 2003 Jun;51(6):1427-9. doi: 10.1093/jac/dkg230. Epub 2003 Apr 25.
6
Nosocomial bloodstream infections in United States hospitals: a three-year analysis.美国医院的医院获得性血流感染：一项为期三年的分析。
Clin Infect Dis. 1999 Aug;29(2):239-44. doi: 10.1086/520192.
7
Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC).癌症患者念珠菌血症：欧洲癌症研究与治疗组织（EORTC）侵袭性真菌感染小组（IFIG）的一项前瞻性多中心监测研究。
Clin Infect Dis. 1999 May;28(5):1071-9. doi: 10.1086/514731.
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Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans.光滑念珠菌：与白色念珠菌相比的流行病学、发病机制及临床疾病综述
Clin Microbiol Rev. 1999 Jan;12(1):80-96. doi: 10.1128/CMR.12.1.80.

卡泊芬净联合两性霉素B治疗光滑念珠菌感染

Caspofungin in combination with amphotericin B against Candida glabrata.

作者信息

Barchiesi Francesco, Spreghini Elisabetta, Fothergill Annette W, Arzeni Daniela, Greganti Gianfranco, Giannini Daniele, Rinaldi Michael G, Scalise Giorgio

机构信息

Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliera-Universitaria, Ospedali Riuniti, Umberto I-G.M. Lancisi-G. Salesi, Ancona, Italy.

出版信息

Antimicrob Agents Chemother. 2005 Jun;49(6):2546-9. doi: 10.1128/AAC.49.6.2546-2549.2005.

DOI:10.1128/AAC.49.6.2546-2549.2005
PMID:15917570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1140549/
Abstract

The effects of caspofungin combined with amphotericin B were investigated with Candida glabrata. Although in vitro experiments showed an indifferent interaction, the combination regimen was the only therapeutic approach yielding organ sterilization in a murine candidemia model.

摘要

研究了卡泊芬净联合两性霉素B对光滑念珠菌的作用。尽管体外实验显示二者相互作用不明显，但在小鼠念珠菌血症模型中，联合用药方案是实现器官除菌的唯一治疗方法。