Carpenter S, Kraus G A
Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames 50011.
Photochem Photobiol. 1991 Feb;53(2):169-74. doi: 10.1111/j.1751-1097.1991.tb03919.x.
Hypericin, a photoreactive polycyclic quinone, was found to dramatically reduce infectivity of cell-free stocks of equine infectious anemia virus. However, the antiviral activity of hypericin was completely dependent on the presence of light. Short periods of photosensitization resulted in a partial loss of reverse transcriptase activity and complete inhibition of viral infectivity. These results suggest that the photodynamic effect of hypericin interferes with more than one stage in the virus replication cycle.
金丝桃素是一种光反应性多环醌，已发现它能显著降低马传染性贫血病毒无细胞毒株的感染性。然而，金丝桃素的抗病毒活性完全依赖于光的存在。短时间的光致敏导致逆转录酶活性部分丧失，并完全抑制病毒感染性。这些结果表明，金丝桃素的光动力效应会干扰病毒复制周期中的多个阶段。
