Park J, English D S, Wannemuehler Y, Carpenter S, Petrich J W
Department of Chemistry, Iowa State University, Ames 50011-3111, USA.
Photochem Photobiol. 1998 Oct;68(4):593-7.
The light-induced antiviral activity of hypericin and hypocrellin in the presence and absence of oxygen was examined under experimental conditions where the effect of oxygen depletion could be quantified. There was a significant reduction of light-induced antiviral activity of hypericin and hypocrellin under hypoxic conditions. Interestingly, antiviral activity of hypocrellin was not observed at low oxygen levels at which hypericin retained measurable virucidal activity. This suggests that additional pathways, such as the generation of protons from excited states of hypericin, may enhance the biological activity of activated oxygen species.
在可以对氧消耗的影响进行量化的实验条件下，研究了金丝桃素和竹红菌素在有氧和无氧情况下的光诱导抗病毒活性。在缺氧条件下，金丝桃素和竹红菌素的光诱导抗病毒活性显著降低。有趣的是，在低氧水平下未观察到竹红菌素的抗病毒活性，而此时金丝桃素仍保留可测量的杀病毒活性。这表明，其他途径，如金丝桃素激发态产生质子，可能会增强活性氧的生物活性。
