Moss T, Stefanovsky V, Langlois F, Gagnon-Kugler T
Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ-HDQ, Pavillon St. Patrick, 9 rue McMahon, QC, Canada G1R 3S3.
Biochem Soc Trans. 2006 Dec;34(Pt 6):1079-81. doi: 10.1042/BST0341079.
Ribosome assembly occurs co-transcriptionally on the rRNA genes. This process requires the co-ordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. Co-ordinate regulation of the rRNA genes and the ribosomal protein genes is therefore essential for high-fidelity ribosome assembly. Recent work shows that rRNA gene transcription is regulated at the level of elongation via the mitogen-activated protein kinase pathway. We argue that this may provide an explanation for the high fidelity of ribosome assembly.
核糖体组装在rRNA基因上与转录同时发生。这个过程需要数百种蛋白质的协同表达和组装，并且被精确地调节以适应细胞和生物体的生长。因此，rRNA基因和核糖体蛋白基因的协同调节对于高保真核糖体组装至关重要。最近的研究表明，rRNA基因转录在延伸水平上通过丝裂原活化蛋白激酶途径受到调控。我们认为这可能为核糖体组装的高保真度提供一种解释。
