Toida M, Okumura Y, Takami T
Department of Oral Surgery and Oral Medicine, Ibi General Hospital, Gifu-prefecture, Japan.
J Clin Pathol. 1991 Mar;44(3):255-6. doi: 10.1136/jcp.44.3.255.
To show the clinical importance of cells containing FXIIIa in pulmonary fibrosis induced by bleomycin, the distributions of FXIIIa and collagenous components were investigated immunohistochemically in both normal lung tissues and those affected by bleomycin. In the normal tissues FXIIIa-containing cells were sparse, but they were numerous in the pulmonary fibrotic tissues, especially in the subpleural area and around the blood vessels of alveolar septa, where slight to moderate fibrosis was seen, and in the intra-alveolar fibrinous exudate. In the collagenous scar-like areas, however, these cells were fewer in number and their FXIIIa expression was depleted. These findings suggest that cells containing FXIIIa have an important role in the development of pulmonary fibrosis induced by bleomycin.
为了揭示含FXIIIa的细胞在博来霉素诱导的肺纤维化中的临床重要性，我们采用免疫组织化学方法研究了FXIIIa和胶原成分在正常肺组织以及博来霉素所致病变肺组织中的分布情况。在正常组织中，含FXIIIa的细胞稀少，但在肺纤维化组织中数量众多，尤其是在胸膜下区域以及肺泡间隔血管周围，这些部位可见轻度至中度纤维化，并且在肺泡内纤维蛋白渗出物中也有大量含FXIIIa的细胞。然而，在胶原瘢痕样区域，这些细胞数量较少且FXIIIa表达减少。这些发现表明，含FXIIIa的细胞在博来霉素诱导的肺纤维化发展过程中起重要作用。
