博来霉素刺激的仓鼠肺泡巨噬细胞释放白细胞介素-1。
Bleomycin-stimulated hamster alveolar macrophages release interleukin-1.
作者信息
Suwabe A, Takahashi K, Yasui S, Arai S, Sendo F
机构信息
First Department of Intenral Medicine, Yamagata University School of Medicine, Japan.
出版信息
Am J Pathol. 1988 Sep;132(3):512-20.
Abstract
The capacity of alveolar macrophages (AM) of bleomycin-instilled hamsters to proliferate mouse thymocytes (interleukin-1 activity) and hamster fibroblasts (fibroblast proliferation (FP) activity was studied. Using bleomycin-instilled hamsters, the FP activity of AM culture supernatants was increased significantly on days 1, 5, and 10 after instillation of bleomycin. The interleukin-1 (IL-1) activity, however, was increased significantly on day 1 only as compared with saline-treated hamsters. Next, normal AM were stimulated in vitro by bleomycin. After being fractionated by chromatography, their culture supernatant showed IL-1 activity, which also indicated FP activity. These results suggest that bleomycin directly stimulates AM to release IL-1 in the fibrogenic responses.
摘要
研究了博来霉素注入仓鼠后肺泡巨噬细胞（AM）增殖小鼠胸腺细胞的能力（白细胞介素-1活性）以及仓鼠成纤维细胞（成纤维细胞增殖（FP）活性）。使用博来霉素注入的仓鼠，在注入博来霉素后的第1、5和10天，AM培养上清液的FP活性显著增加。然而，与生理盐水处理的仓鼠相比，白细胞介素-1（IL-1）活性仅在第1天显著增加。接下来，用博来霉素体外刺激正常AM。经色谱分离后，其培养上清液显示出IL-1活性，这也表明存在FP活性。这些结果表明，在纤维化反应中，博来霉素直接刺激AM释放IL-1。
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