Wang Philip S, Brookhart M Alan, Setoguchi Soko, Patrick Amanda R, Schneeweiss Sebastian
Department of Psychiatry, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA.
Curr Neurol Neurosci Rep. 2006 Nov;6(6):490-5. doi: 10.1007/s11910-006-0051-6.
Behavioral disturbances associated with dementia are common and burdensome. Although no psychotropic medications are currently approved by the US Food and Drug Administration (FDA) to treat such behavioral symptoms, a variety of drug classes are commonly used for these purposes. Atypical antipsychotic medications may be somewhat effective and are generally considered the pharmacologic treatments of choice; however "black box" warnings have recently been added to their labels by the FDA, warning of significantly increased risks of short-term mortality. Older conventional antipsychotic medications may also be somewhat effective but appear to pose risks that can be at least as great as those of the newer atypical drugs. Although antidepressants, benzodiazepines, mood stabilizers, acetylcholinesterase inhibitors, and N-methyl-D-aspartate (NMDA) receptor antagonists may be considered, particularly in patients with specific types of symptomatology, even less is known about their effectiveness and safety. Also, although various psychotropic medications used for behavioral disturbances in dementia patients may be somewhat effective, they have been increasingly associated with important safety risks.
与痴呆症相关的行为障碍很常见且负担沉重。尽管目前美国食品药品监督管理局（FDA）尚未批准任何精神药物用于治疗此类行为症状，但多种药物类别通常用于此目的。非典型抗精神病药物可能有一定疗效，通常被认为是首选的药物治疗方法；然而，FDA最近在其标签上添加了“黑框”警告，警示短期死亡率显著增加的风险。 older conventional antipsychotic medications may also be somewhat effective but appear to pose risks that can be at least as great as those of the newer atypical drugs. 虽然抗抑郁药、苯二氮䓬类药物、心境稳定剂、乙酰胆碱酯酶抑制剂和N-甲基-D-天冬氨酸（NMDA）受体拮抗剂也可考虑使用，尤其是针对特定症状类型的患者，但人们对它们的有效性和安全性了解更少。此外，尽管用于痴呆症患者行为障碍的各种精神药物可能有一定疗效，但它们与重要的安全风险的关联日益增加。 （注：原文中“older conventional antipsychotic medications may also be somewhat effective but appear to pose risks that can be at least as great as those of the newer atypical drugs.”翻译时前面“older conventional antipsychotic medications”表述不完整，推测可能是“老一代传统抗精神病药物”，整体翻译供你参考，你可根据完整准确原文进一步调整。）
