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Francisella novicida LPS has greater immunobiological activity in mice than F. tularensis LPS, and contributes to F. novicida murine pathogenesis.新凶手弗朗西斯菌脂多糖在小鼠体内比土拉弗朗西斯菌脂多糖具有更强的免疫生物学活性，并且在新凶手弗朗西斯菌的小鼠致病过程中起作用。
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A Francisella tularensis subspecies novicida purF mutant, but not a purA mutant, induces protective immunity to tularemia in mice.土拉热弗朗西斯菌新凶手亚种purF突变株而非purA突变株可诱导小鼠对土拉菌病产生保护性免疫。
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本文引用的文献

1
Direct biochemical evidence for the utilization of UDP-bacillosamine by PglC, an essential glycosyl-1-phosphate transferase in the Campylobacter jejuni N-linked glycosylation pathway.空肠弯曲菌N-连接糖基化途径中一种必需的糖基-1-磷酸转移酶PglC利用UDP-杆菌胺的直接生化证据。
Biochemistry. 2006 Apr 25;45(16):5343-50. doi: 10.1021/bi0602056.
2
Francisella tularensis travels a novel, twisted road within macrophages.土拉弗朗西斯菌在巨噬细胞内走出了一条独特而曲折的路径。
Trends Microbiol. 2006 Jan;14(1):37-44. doi: 10.1016/j.tim.2005.11.008. Epub 2005 Dec 13.
3
Grey variants of the live vaccine strain of Francisella tularensis lack lipopolysaccharide O-antigen, show reduced ability to survive in macrophages and do not induce protective immunity in mice.土拉弗朗西斯菌活疫苗株的灰色变体缺乏脂多糖O抗原，在巨噬细胞中的存活能力降低，并且不能在小鼠中诱导保护性免疫。
Vaccine. 2006 Feb 13;24(7):989-96. doi: 10.1016/j.vaccine.2005.08.075. Epub 2005 Sep 6.
4
Intraspecies and temperature-dependent variations in susceptibility of Yersinia pestis to the bactericidal action of serum and to polymyxin B.鼠疫耶尔森菌对血清杀菌作用及多粘菌素B敏感性的种内差异和温度依赖性变化。
Infect Immun. 2005 Nov;73(11):7324-31. doi: 10.1128/IAI.73.11.7324-7331.2005.
5
Evolution of subspecies of Francisella tularensis.土拉弗朗西斯菌亚种的进化
J Bacteriol. 2005 Jun;187(11):3903-8. doi: 10.1128/JB.187.11.3903-3908.2005.
6
Mice sublethally infected with Francisella novicida U112 develop only marginal protective immunity against systemic or aerosol challenge with virulent type A or B strains of F. tularensis.用新凶手弗朗西斯菌U112进行亚致死感染的小鼠，对强毒A型或B型土拉弗朗西斯菌的全身或气溶胶攻击仅产生微弱的保护性免疫。
Microb Pathog. 2004 Aug;37(2):107-10. doi: 10.1016/j.micpath.2004.04.005.
7
Protection afforded by heat shock protein 60 from Francisella tularensis is due to copurified lipopolysaccharide.来自土拉热弗朗西斯菌的热休克蛋白60所提供的保护作用归因于共纯化的脂多糖。
Infect Immun. 2004 Jul;72(7):4109-13. doi: 10.1128/IAI.72.7.4109-4113.2004.
8
Lipopolysaccharide O antigen status of Yersinia enterocolitica O:8 is essential for virulence and absence of O antigen affects the expression of other Yersinia virulence factors.小肠结肠炎耶尔森氏菌O:8的脂多糖O抗原状态对其毒力至关重要，且O抗原的缺失会影响其他耶尔森氏菌毒力因子的表达。
Mol Microbiol. 2004 Apr;52(2):451-69. doi: 10.1111/j.1365-2958.2004.03987.x.
9
Characterization of the lipopolysaccharide O-antigen of Francisella novicida (U112).新凶手弗朗西斯菌（U112）脂多糖O抗原的特性分析
Carbohydr Res. 2004 Feb 25;339(3):649-54. doi: 10.1016/j.carres.2003.12.013.
10
The Klebsiella pneumoniae O antigen contributes to bacteremia and lethality during murine pneumonia.肺炎克雷伯菌O抗原在小鼠肺炎期间会导致菌血症和致死率增加。
Infect Immun. 2004 Mar;72(3):1423-30. doi: 10.1128/IAI.72.3.1423-1430.2004.

来自土拉弗朗西斯菌土拉亚种和新凶手弗朗西斯菌的免疫特性不同的O抗原既是毒力决定因素，也是保护性抗原。

The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens.

作者信息

Thomas Rebecca M, Titball Richard W, Oyston Petra C F, Griffin Kate, Waters Emma, Hitchen Paul G, Michell Stephen L, Grice I Darren, Wilson Jennifer C, Prior Joann L

机构信息

Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, United Kingdom.

出版信息

Infect Immun. 2007 Jan;75(1):371-8. doi: 10.1128/IAI.01241-06. Epub 2006 Oct 30.

DOI:10.1128/IAI.01241-06
PMID:17074846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1828428/
Abstract

We have determined the sequence of the gene cluster encoding the O antigen in Francisella novicida and compared it to the previously reported O-antigen cluster in Francisella tularensis subsp. tularensis. Immunization with purified lipopolysaccharide (LPS) from F. tularensis subsp. tularensis or F. novicida protected against challenge with Francisella tularensis subsp. holarctica and F. novicida, respectively. The LPS from F. tularensis subsp. tularensis did not confer protection against challenge with F. novicida, and the LPS from F. novicida did not confer protection against challenge with F. tularensis subsp. holarctica. Allelic replacement mutants of F. tularensis subsp. tularensis or F. novicida which failed to produce O antigen were attenuated, but exposure to these mutants did not induce a protective immune response. The O antigen of F. tularensis subsp. tularensis appeared to be important for intracellular survival whereas the O antigen of F. novicida appeared to be critical for serum resistance and less important for intracellular survival.

摘要

我们已经确定了新凶手弗朗西斯菌中编码O抗原的基因簇序列，并将其与之前报道的土拉热弗朗西斯菌亚种土拉热弗朗西斯菌中的O抗原簇进行了比较。用来自土拉热弗朗西斯菌亚种土拉热弗朗西斯菌或新凶手弗朗西斯菌的纯化脂多糖（LPS）进行免疫，分别可抵御土拉热弗朗西斯菌亚种全北区亚种和新凶手弗朗西斯菌的攻击。来自土拉热弗朗西斯菌亚种土拉热弗朗西斯菌的LPS不能抵御新凶手弗朗西斯菌的攻击，来自新凶手弗朗西斯菌的LPS也不能抵御土拉热弗朗西斯菌亚种全北区亚种的攻击。不能产生O抗原的土拉热弗朗西斯菌亚种土拉热弗朗西斯菌或新凶手弗朗西斯菌的等位基因替换突变体毒力减弱，但接触这些突变体不会诱导保护性免疫反应。土拉热弗朗西斯菌亚种土拉热弗朗西斯菌的O抗原似乎对细胞内存活很重要，而新凶手弗朗西斯菌的O抗原似乎对血清抗性至关重要，对细胞内存活的重要性较低。