Ndoye Roth P A, Ba E A, Wane A M, De Meideros M, Dieng M, Ka A, Sow M N, Ndiaye M R, Wade A
Clinique Ophtalmologique, Centre Hospitalier Universitaire Aristide Le Dantec, Dakar, Sénégal.
J Fr Ophtalmol. 2006 Oct;29(8):e19. doi: 10.1016/s0181-5512(06)70120-6.
Fungal infection is rarely investigated in keratitis. The authors report five cases of fungal keratitis observed at the le Dantec University Teaching Hospital of Dakar, Senegal, involving two males and three females. Diagnosis was made by examination of smears and cultures of corneal scrapings revealing Candida albicans isolated in four patients and Acremonium strictium in another after 2 or 12 weeks of treatment with antibiotics, antivirals, or steroids. Povidone iodine 2.3% concentrated eye drop was used alone or with an azole for 4 a mean of weeks. All patients presented corneal scars. Fungal keratitis must be considered in presence of torpid corneal ulcer and corneal scraping must be systematically done. Topical povidone iodine alone or associated with azole may be an alternative fungal keratitis treatment in intertropical areas.
角膜炎患者中真菌感染很少被研究。作者报告了在塞内加尔达喀尔勒丹泰克大学教学医院观察到的5例真菌性角膜炎病例，其中男性2例，女性3例。诊断通过检查角膜刮片的涂片和培养进行，结果显示在使用抗生素、抗病毒药物或类固醇治疗2周或12周后，4例患者分离出白色念珠菌，另1例分离出紧密枝顶孢霉。单独使用2.3%聚维酮碘浓缩滴眼液或与唑类药物联合使用，平均使用4周。所有患者均出现角膜瘢痕。在存在迁延不愈的角膜溃疡时必须考虑真菌性角膜炎，并且必须系统地进行角膜刮片检查。在热带地区，单独使用局部聚维酮碘或与唑类药物联合使用可能是真菌性角膜炎的一种替代治疗方法。
