McCulley James P, Shine Ward E
Department of Ophthalmology, University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
Ocul Surf. 2003 Jul;1(3):97-106. doi: 10.1016/s1542-0124(12)70138-6.
The meibomian glands of the lid produce a lipid material whose synthesis is dependent on neuronal, hormonal, and vascular factors. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier and must remain functional after a blink. To satisfy these requirements, the meibomian lipids have a specific composition. Even after delivery it may be modified by lipases produced by ocular bacteria, and modifications in the lipid components can lead to unique disease states. For example, bacteria may degrade lipids, producing an unstable tear film and irritating free fatty acids; and hormonal imbalances may alter lipid profiles to destabilize the tear film and produce evaporative dry eye.
眼睑的睑板腺分泌一种脂质物质，其合成依赖于神经、激素和血管因素。这种脂质物质呈液态，易于扩散，既是一种表面活性剂，也是一种水性屏障，并且在眨眼后必须保持功能正常。为满足这些要求，睑板腺脂质具有特定的组成。即使在分泌后，它也可能被眼部细菌产生的脂肪酶修饰，脂质成分的改变会导致独特的疾病状态。例如，细菌可能会降解脂质，产生不稳定的泪膜并释放刺激性游离脂肪酸；激素失衡可能会改变脂质分布，使泪膜不稳定并导致蒸发型干眼。
