McCulley James P, Shine Ward E
Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9057, USA.
Exp Eye Res. 2004 Mar;78(3):361-5. doi: 10.1016/s0014-4835(03)00203-3.
There is growing laboratory and clinical evidence implicating the meibomian glands of the eyelid as playing a critical role in the pathogenesis of various ocular surface disorders such as chronic blepharitis and dry eye. Meibomian glands produce a lipid material whose synthesis is dependent on factors such as stem cells, neurological stimulants and hormones. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier, and must remain functional after a blink. Before delivery it can be modified by factors such as hormone abnormalities and even after delivery it may be modified by lipases produced by ocular bacteria.
越来越多的实验室和临床证据表明，眼睑睑板腺在各种眼表疾病（如慢性睑缘炎和干眼症）的发病机制中起着关键作用。睑板腺产生一种脂质物质，其合成依赖于干细胞、神经刺激物和激素等因素。这种脂质物质呈流体状，易于扩散，既是一种表面活性剂，也是一种水性屏障，并且在眨眼后必须保持功能正常。在排出之前，它可能会受到激素异常等因素的影响而发生改变，甚至在排出后，它也可能会被眼部细菌产生的脂肪酶所改变。
