Muthayya S, Dwarkanath P, Mhaskar M, Mhaskar R, Thomas A, Duggan Cp, Fawzi W W, Bhat S, Vaz M, Kurpad Av
Division of Nutrition, Institute of Population Health and Clinical Research, St John's National Academy of Health Sciences, Bangalore, India.
Asia Pac J Clin Nutr. 2006;15(4):538-43.
Earlier studies have shown a relationship between maternal vitamin B12 status and birth weight. This study extends those findings directly in terms of neonatal vitamin B12 status and birth weight. One hundred and twelve women were followed from the first trimester of pregnancy and maternal blood was obtained in all three trimesters along with cord blood at birth of their neonates. The maternal and cord serum vitamin B12 concentrations were examined in relation to birth weight. There was a significant correlation between vitamin B12 concentration in maternal antenatal serum during each of the trimesters of pregnancy and cord serum (all P< 0.01). Neonates that were born with lower birth weights (categories of <2500 g and 2500-2999g) had significantly lower mean cord serum vitamin B12 concentrations when compared to those who were > or = 3000g (P = 0.02 and P = 0.05 respectively). A similar, however, non significant trend was observed for antenatal vitamin B12 concentrations at first and third trimesters. Cord serum vitamin B12 concentrations were significantly correlated with birth weight, up to 40 weeks of pregnancy (r=0.28, P=0.01) but not beyond that (> or =40 weeks gestation). Vitamin B12 status in the mother was related to neonatal vitamin B12 status as measured by cord serum vitamin B12 concentration. In addition, low neonatal vitamin B12 concentrations were adversely associated with low birth weights.
早期研究表明母体维生素B12状态与出生体重之间存在关联。本研究直接就新生儿维生素B12状态和出生体重对这些发现进行了拓展。112名女性从妊娠早期开始接受跟踪，在所有三个孕期均采集了母体血液，并在其新生儿出生时采集了脐带血。检测了母体和脐带血清维生素B12浓度与出生体重的关系。妊娠各孕期母体产前血清中的维生素B12浓度与脐带血清中的维生素B12浓度之间存在显著相关性（所有P<0.01）。与出生体重≥3000g的新生儿相比，出生体重较低（<2500g和2500 - 2999g类别）的新生儿脐带血清维生素B12平均浓度显著较低（分别为P = 0.02和P = 0.05）。然而，在孕早期和孕晚期的产前维生素B12浓度方面观察到了类似但不显著的趋势。直至妊娠40周，脐带血清维生素B12浓度与出生体重显著相关（r = 0.28，P = 0.01），但超过40周（≥40周妊娠）则无此关联。母亲的维生素B12状态与通过脐带血清维生素B12浓度衡量的新生儿维生素B12状态相关。此外，新生儿维生素B12浓度低与低出生体重呈负相关。
