韦利司他汀核心结构的合成。

A synthesis of the welwistatin core.

作者信息

Lauchli Ryan, Shea Kenneth J

机构信息

Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, Irvine, California 92697-2025, USA.

出版信息

Org Lett. 2006 Nov 9;8(23):5287-9. doi: 10.1021/ol0620747.

DOI:10.1021/ol0620747

PMID:17078699

Abstract

[Structure: see text] An approach to the core structure of the microtubule-targeting agent welwistatin is described. The approach utilizes the type 2 intramolecular Diels-Alder reaction, with indole serving as the tether between diene and dienophile, to form the natural product's characteristic bicyclo[4.3.1]decane skeleton.

摘要

[结构：见正文] 描述了一种针对微管靶向剂韦维斯他汀核心结构的方法。该方法利用2型分子内狄尔斯-阿尔德反应，以吲哚作为二烯和亲双烯体之间的连接基，形成天然产物特有的双环[4.3.1]癸烷骨架。