Altschuler S M, Ferenci D A, Lynn R B, Miselis R R
Division of Gastroenterology and Nutrition, Children's Hospital of Philadelphia, Pennsylvania.
J Comp Neurol. 1991 Feb 8;304(2):261-74. doi: 10.1002/cne.903040209.
Motor fibers of the accessory celiac and celiac vagal branches are derived from the lateral columns of the dorsal motor nucleus of the vagus nerve. These branches also contain sensory fibers that terminate within the nucleus of the tractus solitarii. This study traces the innervation of the intestines by using the tracer cholera toxin-horseradish peroxidase. In 53 rats, the tracer was injected into either the stomach, duodenum, jejunum, terminal ileum, cecum, or ascending colon. With all cecal injections, prominent retrograde labeling of cell bodies occurred bilaterally in the lateral columns of the dorsal motor nucleus of the vagus nerve above, at, and below the level of the area postrema. Dendrites of laterally positioned neurons projected medially and rostrocaudally within the dorsal motor nucleus of the vagus nerve and dorsomedially into both the medial subnucleus and parts of the commissural subnucleus of the nucleus of the tractus solitarii. Sensory terminal labeling occurred in the dorsolateral commissural subnucleus at the level of the rostral area postrema and the medial commissural subnucleus caudal to the area postrema. Additionally, there was sensory terminal labeling within a small confined area of the dorsomedial zone of the nucleus of the tractus solitarii immediately adjacent to the fourth ventricle at a level just anterior to the area postrema. Stomach injections labeled motoneurons of the medial column of the entire rostrocaudal extent of the dorsal motor nucleus of the vagus nerve and a sensory terminal field primarily in the subnucleus gelatinosus, with less intense labeling extending caudally into the medial and ventral commissural subnuclei. Dendrites of gastric motoneurons project rostrocaudally and mediolaterally within the dorsal motor nucleus of the vagus nerve and dorsolaterally within the nucleus of the tractus solitarii. They are most pronounced at the level of the rostral area postrema where many dendrites course dorsolaterally terminating primarily within the subnucleus gelatinosus. Injections of the duodenum labeled a small number of the cells within the medial aspects of the dorsal motor nucleus of the vagus nerve. Jejunal, ileal, and ascending colon injections labeled cells sparsely within the lateral aspects of the dorsal motor nucleus of the vagus nerve bilaterally. No afferent terminal labeling was evident after injection of these areas of the bowel.(ABSTRACT TRUNCATED AT 400 WORDS)
腹腔支和迷走神经腹腔支的运动纤维源自迷走神经背运动核的外侧柱。这些分支还包含终止于孤束核内的感觉纤维。本研究通过使用示踪剂霍乱毒素 - 辣根过氧化物酶追踪肠道的神经支配。在53只大鼠中，将示踪剂注入胃、十二指肠、空肠、回肠末端、盲肠或升结肠。所有盲肠注射后，在最后区水平上方、处和下方的迷走神经背运动核外侧柱中双侧出现明显的细胞体逆行标记。外侧定位神经元的树突在迷走神经背运动核内沿内侧和前后方向投射，并向背内侧投射到孤束核的内侧亚核和部分连合亚核。感觉终末标记出现在最后区嘴侧水平的背外侧连合亚核和最后区尾侧的内侧连合亚核。此外，在最后区前方水平紧邻第四脑室的孤束核背内侧区的一个小局限区域内有感觉终末标记。胃注射标记了迷走神经背运动核整个前后范围内侧柱的运动神经元以及主要在胶状亚核的感觉终末场，较弱标记向尾侧延伸至内侧和腹侧连合亚核。胃运动神经元的树突在迷走神经背运动核内沿前后和内外方向投射，并在孤束核内沿背外侧方向投射。它们在最后区嘴侧水平最为明显，许多树突沿背外侧走行，主要终止于胶状亚核内。十二指肠注射标记了迷走神经背运动核内侧部分的少量细胞。空肠、回肠和升结肠注射双侧在迷走神经背运动核外侧部分稀疏标记细胞。肠的这些区域注射后未发现明显的传入终末标记。（摘要截短于400字）
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