Altschuler S M, Escardo J, Lynn R B, Miselis R R
Division of Gastroenterology and Nutrition, Children's Hospital of Philadelphia, Pennsylvania.
Gastroenterology. 1993 Feb;104(2):502-9. doi: 10.1016/0016-5085(93)90419-d.
The extent to which the vagus nerve innervates the colon remains controversial.
In 29 rats the tracer cholera toxin-horseradish peroxidase was injected into the cecum, the ascending, transverse, or descending colon or the rectum. For comparison, control injections were made into the stomach.
For all areas of colon except the rectum, brainstem motoneuronal labeling was limited to the lateral third of the dorsal motor nucleus of the vagus nerve bilaterally. In contrast, gastric injections resulted in motoneuronal labeling limited to the medial portions of the nucleus. The number of labeled motoneurons was greatest following injection of the cecum, and it significantly decreased for the more distal areas of the colon. Colonic motoneuron dendrites projected into the nucleus of the solitary tract and within the dorsal motor nucleus of the vagus nerve. Sensory afferent terminal labeling was limited to the commissural and medial subnuclei of the nucleus of the solitary tract. For the rectum, sensory and motor labeling was limited to the spinal cord.
The distribution of labeling within the vagal complex indicates that all regions of the colon, except the rectum, are innervated by the celiac and accessory celiac branches of the vagus nerve.
迷走神经对结肠的支配范围仍存在争议。
对29只大鼠，将示踪剂霍乱毒素 - 辣根过氧化物酶注入盲肠、升结肠、横结肠、降结肠或直肠。作为对照，将其注入胃。
除直肠外，结肠所有区域的脑干运动神经元标记仅限于双侧迷走神经背运动核外侧三分之一。相比之下，注入胃导致运动神经元标记仅限于该核的内侧部分。注入盲肠后标记运动神经元的数量最多，且在结肠更远端区域显著减少。结肠运动神经元树突投射到孤束核和迷走神经背运动核内。感觉传入终末标记仅限于孤束核的连合和内侧亚核。对于直肠，感觉和运动标记仅限于脊髓。
迷走神经复合体中的标记分布表明，除直肠外，结肠的所有区域均由迷走神经的腹腔支和副腹腔支支配。
