Willoughby D A, Dunn C J, Yamamoto S, Capasso F, Deporter D A, Giroud J P
Agents Actions. 1975 Feb;5(1):35-8. doi: 10.1007/BF02027156.
A model is described of acute inflammation in the pleural cavity of rats using calcium pyrophosphate as the irritant. This model would seem to simulate the pseudogout syndrome. It has been shown to be acute in onset, dominated by polymorphonuclear cells, complement independent. The advantage of the model is that volume of exudate, numbers and types of cells may be quantitated. Prostaglandins and cyclic AMP have been measured in the migrating cells. The significance of these findings has been discussed.
描述了一种使用焦磷酸钙作为刺激物在大鼠胸腔内引发急性炎症的模型。该模型似乎可模拟假痛风综合征。已证明其起病急，以多形核细胞为主，与补体无关。该模型的优点在于渗出液的体积、细胞数量及类型均可进行定量分析。已对迁移细胞中的前列腺素和环磷酸腺苷进行了测量。并对这些发现的意义进行了讨论。
