环磷酸腺苷与三种常见抗炎药物的作用机制
Cyclic adenosine 3', 5'-monophosphate and the mechanism of action of three common anti-inflammatory drugs.
作者信息
Deporter D A, Dunn C J, Willoughby D A
出版信息
Br J Pharmacol. 1979 Feb;65(2):163-5. doi: 10.1111/j.1476-5381.1979.tb07814.x.
Abstract
1 The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3', 5'-monophosphate (cyclic AMP) concentration in leucocytes during a crystal-induced pleurisy in rats were studied. 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals. 3 By 6 h, leucocyte cyclic AMP levels returning toward control levels and could not be sustained at the higher level by an additional administration of the respective anti-inflammatory drug.
摘要
- 研究了吲哚美辛、地塞米松和秋水仙碱对大鼠晶体诱导性胸膜炎期间白细胞中环磷酸腺苷（cAMP）浓度的影响。2. 在注射晶体后3小时内，每种药物均显著提高了白细胞cAMP含量。3. 到6小时时，白细胞cAMP水平恢复到对照水平，且再次给予相应的抗炎药物无法使其维持在较高水平。
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Life Sci. 1974 Feb 1;14(3):505-19. doi: 10.1016/0024-3205(74)90365-8.
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