Matthews Erin E, Zoonens Manuela, Engelman Donald M
Department of Chemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.
Cell. 2006 Nov 3;127(3):447-50. doi: 10.1016/j.cell.2006.10.016.
Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned from these examples. Such efforts suggest that some of the most interesting properties of transmembrane helix interactions may be the least amenable to study by current techniques.
研究蛋白质跨膜结构域如何跨膜传递信号面临着独特的挑战。在此，我们讨论促成成功的各种情况，并思考从这些例子中学到了什么。这些研究表明，跨膜螺旋相互作用的一些最有趣的特性可能最不适合用当前技术进行研究。
