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预防脑与心脏血管疾病的免疫调节策略:研讨会总结

Immunomodulation strategies for preventing vascular disease of the brain and heart: workshop summary.

作者信息

Hallenbeck John, Del Zoppo Gregory, Jacobs Tom, Hakim Antoine, Goldman Stephen, Utz Ursula, Hasan Ahmed

机构信息

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 49 Convent Dr, MSC 4476, Bethesda, MD 20892-4476, USA.

出版信息

Stroke. 2006 Dec;37(12):3035-42. doi: 10.1161/01.STR.0000248836.82538.ee. Epub 2006 Nov 2.

DOI:10.1161/01.STR.0000248836.82538.ee
PMID:17082471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853372/
Abstract

This workshop examined the opportunities for translational research directed at immune and inflammatory mechanisms. This summary presents the background data in 3 general areas: (1) inflammation and hemostasis in cerebrovascular and cardiovascular disease, (2) immune interactions in the central nervous system and heart, and (3) translation of immune modulation in the brain and heart, all of which supported a consensus derivation of the opportunities for future research in these areas. The summary concludes with 11 recommendations.

摘要

本次研讨会探讨了针对免疫和炎症机制开展转化研究的机会。本综述介绍了三个一般领域的背景数据:(1)脑血管和心血管疾病中的炎症与止血,(2)中枢神经系统和心脏中的免疫相互作用,以及(3)大脑和心脏中免疫调节的转化,所有这些都为这些领域未来研究机会的共识推导提供了支持。综述最后提出了11条建议。

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本文引用的文献

1
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2
Learning from the TGN1412 trial.从TGN1412试验中吸取教训。
BMJ. 2006 Mar 25;332(7543):677-8. doi: 10.1136/bmj.38797.635012.47. Epub 2006 Mar 22.
3
TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque.表达肿瘤坏死因子相关凋亡诱导配体(TRAIL)的T细胞可诱导动脉粥样硬化斑块中血管平滑肌细胞凋亡。
J Exp Med. 2006 Jan 23;203(1):239-50. doi: 10.1084/jem.20051062. Epub 2006 Jan 17.
4
Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood.免疫细胞有助于成年期神经发生和空间学习能力的维持。
Nat Neurosci. 2006 Feb;9(2):268-75. doi: 10.1038/nn1629. Epub 2006 Jan 15.
5
BDNF-mediated enhancement of inflammation and injury in the aging heart.
Physiol Genomics. 2006 Feb 14;24(3):191-7. doi: 10.1152/physiolgenomics.00165.2005. Epub 2005 Dec 13.
6
Effects of angiotensin II receptor blockade with valsartan on pro-inflammatory cytokines in patients with essential hypertension.缬沙坦阻断血管紧张素II受体对原发性高血压患者促炎细胞因子的影响。
J Cardiovasc Pharmacol. 2005 Dec;46(6):735-9. doi: 10.1097/01.fjc.0000185783.00391.60.
7
Central nervous system injury-induced immune deficiency syndrome.中枢神经系统损伤诱导的免疫缺陷综合征
Nat Rev Neurosci. 2005 Oct;6(10):775-86. doi: 10.1038/nrn1765.
8
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J Neurosci. 2005 Sep 7;25(36):8217-28. doi: 10.1523/JNEUROSCI.1859-05.2005.
9
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J Clin Invest. 2005 Sep;115(9):2508-16. doi: 10.1172/JCI24403.
10
The case for intensive statin therapy after acute coronary syndromes.急性冠状动脉综合征后强化他汀治疗的情况
Am J Cardiol. 2005 Sep 5;96(5A):45F-53F. doi: 10.1016/j.amjcard.2005.06.026.