Knopf H L, Hierholzer J C
Am J Ophthalmol. 1975 Oct;80(4):661-72. doi: 10.1016/0002-9394(75)90398-0.
Of 120 individuals suffering from follicular conjunctivitis, with or without keratitis, 56 had epidemic keratoconjunctivitis caused by adenovirus type 8. The remaining 64 patients had keratoconjunctivitis produced by several different viruses, including herpes simplex, adenoviruses types 3, 7, 8, 16, 21, and 29, and others. Positive viral cultures were difficult to obtain after the first week of illness in most viral infections. Serologic tests were far more successful in indetifying causative agents. Hemagglutination-inhibition tests in adenovirus infections proved to be fast, accurate, and more sensitive than other serologic tests. Among the epidemic and nonepidemic adenovirus groups, the degree of corneal involvement in the infections appeared to be correlated with the level antibody against the infectious agent. Patients with low antibody titers had more severe keratitis than those with high titers. This correlation was true for both the epidemic and non epidemic patients.
在120例患有滤泡性结膜炎（伴有或不伴有角膜炎）的患者中，56例患有由8型腺病毒引起的流行性角结膜炎。其余64例患者的角结膜炎由几种不同病毒引起，包括单纯疱疹病毒、3型、7型、8型、16型、21型和29型腺病毒等。在大多数病毒感染中，发病第一周后很难获得病毒培养阳性结果。血清学检测在确定病原体方面要成功得多。腺病毒感染中的血凝抑制试验被证明比其他血清学检测快速、准确且更灵敏。在流行性和非流行性腺病毒组中，感染时角膜受累程度似乎与针对感染病原体的抗体水平相关。抗体滴度低的患者比抗体滴度高的患者角膜炎更严重。这种相关性在流行性和非流行性患者中均成立。
