Darougar S, Hunter P A, Viswalingam M, Gibson J A, Jones B R
Br J Ophthalmol. 1978 Dec;62(12):843-9. doi: 10.1136/bjo.62.12.843.
During the 18 months January 1975 to June 1976, 25 cases of acute herpetic follicular conjunctivitis and keratoconjunctivitis resembling adenovirus ocular infection presented in the External Eye Disease Clinic, Moorfields Eye Hospital, City Road, London. Herpes simplex virus was isolated in HEp2 cells in 22 patients, and the remaining 3 patients were identified by a minimum 4-fold rise in the level of antiherpes simplex virus antibody in their blood. No adenovirus was isolated from these patients, but complement fixation test for adenovirus was positive in 1 patient with cultural test positive for herpes simplex virus. Most patients were between 20 and 35 years old and the ratio of males to females was 12 to 13. At the initial visit the clinical features of disease were moderate to severe conjunctival papillary and follicular reasons with epithelial and subepithelial punctate keratitis but little systemic disease. In the absence of typical herpetic lesions of face, lids, or cornea the disease resembled adenovirus types 8 or 19 keratoconjunctivitis. Of these 25 patients 5 subsequently developed typical herpetic lesions of lids or cornea. In the remaining 20 cases the correct diagnosis could be made only by cultural or serological tests. Virological diagnosis provides a rational basis for antiherpetic chemotherapy, which appears to shorten the course of infection.
在1975年1月至1976年6月的18个月期间，伦敦市路摩尔菲尔德眼科医院外眼病诊所接诊了25例急性疱疹性滤泡性结膜炎和类似腺病毒眼部感染的角膜结膜炎病例。22例患者的单纯疱疹病毒在人胚肾细胞（HEp2细胞）中分离出来，其余3例患者通过血液中抗单纯疱疹病毒抗体水平至少升高4倍得以确诊。这些患者均未分离出腺病毒，但1例单纯疱疹病毒培养检测呈阳性的患者腺病毒补体结合试验呈阳性。大多数患者年龄在20至35岁之间，男女比例为12比13。初诊时，疾病的临床特征为中度至重度结膜乳头和滤泡形成，伴有上皮和上皮下点状角膜炎，但全身症状较轻。在没有面部、眼睑或角膜典型疱疹性病变的情况下，该疾病类似8型或19型腺病毒角膜结膜炎。这25例患者中有5例随后出现了典型的眼睑或角膜疱疹性病变。在其余20例病例中，只有通过培养或血清学检测才能做出正确诊断。病毒学诊断为抗疱疹化疗提供了合理依据，抗疱疹化疗似乎可以缩短感染病程。
