Cangul I Taci, Gul Nihal Y, Topal Ayse, Yilmaz Rahsan
Department of Pathology, Faculty of Veterinary Medicine, Uludag University, 16059 Gorukle/Bursa, Turkey.
Vet Dermatol. 2006 Dec;17(6):417-23. doi: 10.1111/j.1365-3164.2006.00551.x.
In this study the clinical and histopathological effects of topically applied tripeptide-copper complex (TCC) and zinc oxide on open-wound healing in rabbits was evaluated. Eighteen New Zealand rabbits were divided into three groups: TCC, zinc oxide and no treatment. One full thickness wound was created on each side of the dorsal midline in each rabbit. Wound margins were traced on days 0, 7, 14, and 21 and topical TCC and zinc oxide were applied daily for 21 days to each rabbit in the respective treatment groups. The mean unhealed wound area was significantly smaller in the TCC than in the zinc oxide group on day 7, but it was significantly smaller in the TCC group than in to the control group on days 7, 14 and 21. The mean percentage of wound contraction on day 7 was significantly higher in the TCC than in the zinc oxide group; however, it was significantly higher in the TCC group than in the control group on days 7, 14 and 21. Median time for the coverage of the wound bed with granulation tissue was significantly shorter in the TCC group than in the other groups. Filling of the open wound with granulation tissue to skin level was significantly slower in the control group than in the other two groups. Neutrophil counts decreased regardless of the group in parallel with healing, while neovascularization was best observed in the TCC group. The results suggest that TCC is a better choice in the treatment protocols of open wounds in rabbits than zinc oxide.
本研究评估了局部应用三肽铜络合物（TCC）和氧化锌对兔开放性伤口愈合的临床及组织病理学影响。18只新西兰兔被分为三组：TCC组、氧化锌组和未治疗组。每只兔在背部中线两侧各制造一个全层伤口。在第0、7、14和21天描绘伤口边缘，并对各治疗组的每只兔每天局部应用TCC和氧化锌，持续21天。在第7天，TCC组的平均未愈合伤口面积显著小于氧化锌组，但在第7、14和21天，TCC组的平均未愈合伤口面积显著小于对照组。在第7天，TCC组的伤口收缩平均百分比显著高于氧化锌组；然而，在第7、14和21天，TCC组的伤口收缩平均百分比显著高于对照组。TCC组伤口床被肉芽组织覆盖的中位时间显著短于其他组。对照组开放性伤口被肉芽组织填充至皮肤水平的速度显著慢于其他两组。无论哪一组，中性粒细胞计数均随愈合而下降，而TCC组的新生血管形成情况最佳。结果表明，在兔开放性伤口的治疗方案中，TCC比氧化锌是更好的选择。
