锌离子对BSC-1细胞中单纯疱疹病毒复制的不可逆抑制作用。
Irreversible inhibition of herpes simplex virus replication in BSC-1 cells by zinc ions.
作者信息
Gordon Y J, Asher Y, Becker Y
出版信息
Antimicrob Agents Chemother. 1975 Sep;8(3):377-80. doi: 10.1128/AAC.8.3.377.
Abstract
Zinc sulfate added to the medium of herpes simplex virus-infected BSC-1 cells, at a concentration of 0.1 mM, inhibited the synthesis of infectious virus progeny by 95 to 96%. A concentration of 0.2 mM zinc sulfate inhibited herpes simplex virus synthesis by 99.8% as determined by centrifugation in sucrose gradients and by plaque assay on BSC-1 monolayers. The inhibition of herpes simplex virus replication in BSC-1 cells was found to be irreversible.
摘要
向感染单纯疱疹病毒的BSC - 1细胞培养基中添加浓度为0.1 mM的硫酸锌，可使感染性病毒子代的合成受到95%至96%的抑制。通过在蔗糖梯度中离心以及在BSC - 1单层细胞上进行空斑试验测定，浓度为0.2 mM的硫酸锌可使单纯疱疹病毒的合成受到99.8%的抑制。研究发现，BSC - 1细胞中单纯疱疹病毒复制的抑制是不可逆的。
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