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Irreversible inhibition of herpes simplex virus replication in BSC-1 cells by zinc ions.锌离子对BSC-1细胞中单纯疱疹病毒复制的不可逆抑制作用。
Antimicrob Agents Chemother. 1975 Sep;8(3):377-80. doi: 10.1128/AAC.8.3.377.
2
Effect of zinc ions on synthesis of herpes simplex virus type 2-induced polypeptides.锌离子对2型单纯疱疹病毒诱导的多肽合成的影响。
Proc Soc Exp Biol Med. 1976 Jul;152(3):455-8. doi: 10.3181/00379727-152-39417.
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Inhibition of Herpes simplex virus replication by cordycepin.虫草素对单纯疱疹病毒复制的抑制作用。
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Inhibition of Herpes simplex virus replication by camptothecin.喜树碱对单纯疱疹病毒复制的抑制作用。
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Phosphonoacetic acid-resistant mutants of herpes simplex virus: effect of phosphonoacetic acid on virus replication and in vitro deoxyribonucleic acid synthesis in isolated nuclei.单纯疱疹病毒的膦甲酸钠抗性突变体：膦甲酸钠对病毒复制及分离细胞核中体外脱氧核糖核酸合成的影响
Antimicrob Agents Chemother. 1977 May;11(5):919-22. doi: 10.1128/AAC.11.5.919.
6
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J Gen Virol. 1990 Dec;71 ( Pt 12):2989-97. doi: 10.1099/0022-1317-71-12-2989.
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Effect of zinc ions on the synthesis of herpes simplex virus DNA in infected BSC-1 cells.
Virology. 1975 Jul;66(1):330-5. doi: 10.1016/0042-6822(75)90204-4.
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Antiviral activity of arabinosyladenine and arabinosylhypoxanthine in herpes simplex virus-infected KB cells: selective inhibition of viral deoxyribonucleic acid synthesis in synchronized suspension cultures.阿糖腺苷和阿糖次黄嘌呤在单纯疱疹病毒感染的KB细胞中的抗病毒活性：在同步悬浮培养物中对病毒脱氧核糖核酸合成的选择性抑制
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Reversible inhibition of herpes simplex virus replication by hydroxyurea.羟基脲对单纯疱疹病毒复制的可逆性抑制作用。
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Zinc Sulfate in Narrow Range as an In Vitro Anti-HSV-1 Assay.硫酸锌在窄范围内作为抗单纯疱疹病毒-1 的体外检测方法。
Biol Trace Elem Res. 2020 Feb;193(2):410-413. doi: 10.1007/s12011-019-01728-0. Epub 2019 Apr 26.
3
Zinc and genital infections.
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A combined chemical-physical treatment for herpes simplex lesions in guinea pigs.豚鼠单纯疱疹损伤的化学 - 物理联合治疗
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Specific effect of zinc ions on DNA polymerase activity of avian myeloblastosis virus.
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Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides.锌对鼻病毒蛋白裂解的抑制作用：锌与衣壳多肽的相互作用。
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本文引用的文献

1
TREATMENT OF HERPETIC KERATITIS.疱疹性角膜炎的治疗
Am J Ophthalmol. 1963 Nov;56:729-31. doi: 10.1016/0002-9394(63)92935-0.
2
Characterization of the large picornaviral polypeptides produced in the presence of zinc ion.锌离子存在下产生的大微小核糖核酸病毒多肽的特性分析。
J Virol. 1974 Aug;14(2):282-91. doi: 10.1128/JVI.14.2.282-291.1974.
3
Reversible inhibition of herpes simplex virus replication by hydroxyurea.羟基脲对单纯疱疹病毒复制的可逆性抑制作用。
Antimicrob Agents Chemother. 1973 Mar;3(3):325-31. doi: 10.1128/AAC.3.3.325.
4
Zinc ions inhibit replication of rhinoviruses.锌离子抑制鼻病毒的复制。
Nature. 1974 Apr 12;248(449):588-90. doi: 10.1038/248588a0.
5
[Ca++, histidine, and Zn++ as factors in the formation of giant cells by herpesivirus hominis].[钙离子、组氨酸和锌离子作为人疱疹病毒形成巨细胞的因素]
Z Med Mikrobiol Immunol. 1967;153(3):175-89.
6
Adsorption, penetration and uncoating of herpes simplex virus.单纯疱疹病毒的吸附、穿透及脱壳
J Gen Virol. 1968 Mar;2(2):231-41. doi: 10.1099/0022-1317-2-2-231.
7
Effect of zinc ions on the synthesis of herpes simplex virus DNA in infected BSC-1 cells.
Virology. 1975 Jul;66(1):330-5. doi: 10.1016/0042-6822(75)90204-4.

锌离子对BSC-1细胞中单纯疱疹病毒复制的不可逆抑制作用。

Irreversible inhibition of herpes simplex virus replication in BSC-1 cells by zinc ions.

作者信息

Gordon Y J, Asher Y, Becker Y

出版信息

Antimicrob Agents Chemother. 1975 Sep;8(3):377-80. doi: 10.1128/AAC.8.3.377.

DOI:10.1128/AAC.8.3.377
PMID:170858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429321/
Abstract

Zinc sulfate added to the medium of herpes simplex virus-infected BSC-1 cells, at a concentration of 0.1 mM, inhibited the synthesis of infectious virus progeny by 95 to 96%. A concentration of 0.2 mM zinc sulfate inhibited herpes simplex virus synthesis by 99.8% as determined by centrifugation in sucrose gradients and by plaque assay on BSC-1 monolayers. The inhibition of herpes simplex virus replication in BSC-1 cells was found to be irreversible.

摘要

向感染单纯疱疹病毒的BSC - 1细胞培养基中添加浓度为0.1 mM的硫酸锌，可使感染性病毒子代的合成受到95%至96%的抑制。通过在蔗糖梯度中离心以及在BSC - 1单层细胞上进行空斑试验测定，浓度为0.2 mM的硫酸锌可使单纯疱疹病毒的合成受到99.8%的抑制。研究发现，BSC - 1细胞中单纯疱疹病毒复制的抑制是不可逆的。