单纯疱疹病毒的膦甲酸钠抗性突变体：膦甲酸钠对病毒复制及分离细胞核中体外脱氧核糖核酸合成的影响
Phosphonoacetic acid-resistant mutants of herpes simplex virus: effect of phosphonoacetic acid on virus replication and in vitro deoxyribonucleic acid synthesis in isolated nuclei.
作者信息
Becker Y, Asher Y, Cohen Y, Weinberg-Zahlering E, Shlomai J
出版信息
Antimicrob Agents Chemother. 1977 May;11(5):919-22. doi: 10.1128/AAC.11.5.919.
Abstract
Phosphonoacetic acid (PAA) inhibits the replication of herpes simplex virus in BSC-1 cells and the in vitro synthesis of deoxyribonucleic acid (DNA) in isolated nuclei. Phosphonopropionic acid at a concentration of 100 mug/ml had no effect on herpes simplex virus replication. PAA-resistant mutants were obtained at a rate of 1 in 10(4) plaque-forming units after 5-bromodeoxyuridine mutagenization of the virus. These mutants replicate in BSC-1 cells in the presence of 100 mug of PAA per ml and induce a PAA-resistant DNA polymerase that synthesizes DNA in vitro in the presence of PAA.
摘要
膦乙酸（PAA）可抑制单纯疱疹病毒在BSC - 1细胞中的复制以及分离细胞核中脱氧核糖核酸（DNA）的体外合成。浓度为100μg/ml的膦丙酸对单纯疱疹病毒复制无影响。在用5 - 溴脱氧尿苷对病毒进行诱变后，以每10⁴个噬斑形成单位中有1个的速率获得了PAA抗性突变体。这些突变体在每毫升含有100μg PAA的情况下在BSC - 1细胞中复制，并诱导产生一种PAA抗性DNA聚合酶，该酶在PAA存在的情况下可在体外合成DNA。
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