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酯酶13,一个具有隐性表达的新小鼠酯酶基因座及其在9号染色体上的基因定位。

Esterase 13, a new mouse esterase locus with recessive expression and its genetic location on chromosome 9.

作者信息

Womack J E, Taylor B A, Barton J E

出版信息

Biochem Genet. 1978 Dec;16(11-12):1107-12. doi: 10.1007/BF00484531.

Abstract

A new esterase locus (Es-13) has been identified in Musculus. Strains AEJ/GnRk, LG/J, SJL/J, and SWR/J carry a recessive allele, Es-13b, for a locus possibly involved in the posttranslational modification of a kidney esterase. All other strains observed carried the dominant Es-13a allele. Es-13 was mapped on Chr 9 by recombinant inbred lines and by conventional backcrossing experiments. Backcross data produced the following gene order and map distances: Lap-1 (31.6 +/- 7.5 cM) Es-13 (2.6 +/- 2.6 cM) Mod-1.

摘要

在小家鼠中已鉴定出一个新的酯酶基因座(Es-13)。AEJ/GnRk、LG/J、SJL/J和SWR/J品系携带一个隐性等位基因Es-13b,该基因座可能参与肾脏酯酶的翻译后修饰。观察到的所有其他品系携带显性Es-13a等位基因。通过重组近交系和传统回交实验,将Es-13定位在9号染色体上。回交数据得出以下基因顺序和图距:Lap-1(31.6±7.5厘摩),Es-13(2.6±2.6厘摩),Mod-1。

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