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酯酶-25(Es-25):家鼠一种新的肾芳基酯酶的鉴定与特性分析,该酶在基因上与12号染色体上的Ly-18连锁。

Esterase-25 (Es-25): identification and characterization of a new kidney arylesterase of the house mouse, genetically linked to Ly-18 on chromosome 12.

作者信息

von Deimling O H, Taylor B A

机构信息

Pathologisches Institut, Universität Freiburg, Bundesrepublik Deutschland.

出版信息

Biochem Genet. 1987 Oct;25(9-10):639-46. doi: 10.1007/BF00556208.

Abstract

Genetic variation of a codominantly inherited kidney esterase, designated ES-25, has been discovered in the house mouse using disc electrophoresis. The ES-25A phenotype was found in A strains, AKR, and BALB/c. ES-25B was found in C57BL strains and several other laboratory strains. The enzyme was shown to be controlled by a presumed structural locus, Es-25. The high concordance in 48 RI strains of Es-25 with Ly-18 indicated the location of Es-25 on chromosome 12. The gene order Es-25-Ly-18-D12Nyul-Pre-1 was proposed.

摘要

利用圆盘电泳法,在家鼠中发现了一种共显性遗传的肾脏酯酶(命名为ES - 25)的基因变异。在A品系、AKR和BALB/c中发现了ES - 25A表型。在C57BL品系和其他几个实验室品系中发现了ES - 25B。该酶被证明受一个假定的结构基因座Es - 25控制。在48个重组近交系中,Es - 25与Ly - 18的高度一致性表明Es - 25位于12号染色体上。由此提出了基因顺序Es - 25 - Ly - 18 - D12Nyul - Pre - 1。

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