Penner M, Fingerhut D, Tacke A
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin Westfälischen Wilhelms-Universität Münster.
Infusionstherapie. 1990 Dec;17(6):314-8.
20 patients scheduled for total hip replacement were given 1,000 ml of a new preparation of 10% hydroxyethylstarch (HES) (MW 270,000: 0.5) preoperatively. They were compared to a group of 20 patients who received 1,000 ml of 3.5% plasma protein solution (PPS). HES caused a more pronounced hemodilution than PPS. With HES, central venous pressure (CVP) rose significantly higher than with PPS. PTT was significantly prolonged in the HES but not in the PPS group. TT was significantly reduced by HES in comparison to PPS. PT (Quick-value %) and fibrinogen levels showed no difference in both groups. Blood loss and transfusion volume were comparable to HES and PPS until 24 h after the operation. One patient showed generalised flush after HES. This HES preparation is a colloid with volume-expanding properties and appears to be without clinically apparent effects on coagulation (up to a volume of 11).
20例计划行全髋关节置换术的患者在术前给予1000ml新配制的10%羟乙基淀粉（HES）（分子量270,000：0.5）。将他们与一组接受1000ml 3.5%血浆蛋白溶液（PPS）的20例患者进行比较。HES引起的血液稀释比PPS更明显。使用HES时，中心静脉压（CVP）升高明显高于使用PPS时。HES组的部分凝血活酶时间（PTT）显著延长，而PPS组未延长。与PPS相比，HES使凝血酶时间（TT）显著缩短。两组的凝血酶原时间（Quick值%）和纤维蛋白原水平无差异。术后24小时内，HES组和PPS组的失血量和输血量相当。1例患者在使用HES后出现全身潮红。这种HES制剂是一种具有扩容特性的胶体，似乎对凝血没有明显的临床影响（剂量达11时）。
