Drewes Siegfried E, van Vuuren Sandy F
School of Chemistry, University of KwaZulu-Natal, Private Bag X01, Scottsville, 3209 Pietermaritzburg, South Africa.
Phytochemistry. 2008 May;69(8):1745-9. doi: 10.1016/j.phytochem.2008.02.022. Epub 2008 Apr 10.
From the dichloromethane extract of the flowers of Helichrysum gymnocomum (Asteraceae) two known flavonoids, 4 and 5, and a known acylphloroglucinol, 3B, were isolated. In addition to 1 and 2, the 4',6'-dibenzyloxy-2'-hydroxy derivative of 2',4',6'-trihydroxychalcone and 5,7-dibenzyloxy derivative of pinocembrin, respectively, are reported in Nature for the first time. A compound 3A, related to 3B has the structure 2-methyl-1-[2,4,6-trihydroxy-3-(2-hydroxy-3-methyl-3-butenyl)phenyl]-1-propanone. Compounds 1, 2, 3A, 3B, 4 and 5 have MIC values below 64microg/ml against a selection of pathogens, with 3B having the highest sensitivity (6.3-45microg/ml) for eight of the ten pathogens tested, including Staphylococcus aureus (6.3microg/ml) and methicillin and gentamycin resistant strain of S. aureus (7.8microg/ml). With the exception of 2, the other compounds had notable activity (45-63microg/ml) towards Pseudomonas aeruginosa.
从腊菊（菊科）花的二氯甲烷提取物中分离出两种已知的黄酮类化合物4和5，以及一种已知的酰基间苯三酚3B。除了1和2之外，2',4',6'-三羟基查尔酮的4',6'-二苄氧基-2'-羟基衍生物和松属素的5,7-二苄氧基衍生物也首次在《自然》杂志上报道。与3B相关的化合物3A具有结构2-甲基-1-[2,4,6-三羟基-3-(2-羟基-3-甲基-3-丁烯基)苯基]-1-丙酮。化合物1、2、3A、3B、4和5对一系列病原体的最低抑菌浓度值低于64微克/毫升，其中3B对所测试的十种病原体中的八种具有最高敏感性（6.3 - 45微克/毫升），包括金黄色葡萄球菌（6.3微克/毫升）以及耐甲氧西林和庆大霉素的金黄色葡萄球菌菌株（7.8微克/毫升）。除了2之外，其他化合物对铜绿假单胞菌具有显著活性（45 - 63微克/毫升）。
