Kataoka T, Yamamoto S, Yamamoto T, Tokunaga T
Department of Cellular Immunology, Tokyo.
Jpn J Med Sci Biol. 1990 Oct;43(5):171-82. doi: 10.7883/yoken1952.43.171.
In vivo antitumor activity of a deoxyribonucleic acid fraction obtained from Mycobacterium bovis BCG (named MY-1) increased when it was complexed with poly-L-lysine (poly LL) solubilized by addition of carboxymethylcellulose (CMC). The complex of MY-1 and poly LL/CMC induced interferon in vivo at a low dose of MY-1 which alone exerted no IFN induction. With Line 10 hepatoma (L10) which is syngeneic with strain 2 guinea pigs, it was demonstrated that repeated intralesional injections of the complex resulted in delay of tumor growth and complete cure of animals from L10 tumor inoculated. Similar treatment of the animals with the same amount of MY-1 or poly LL/CMC alone had little therapeutic effect on the tumor growth.
当从牛分枝杆菌卡介苗（命名为MY-1）获得的脱氧核糖核酸组分与通过添加羧甲基纤维素（CMC）增溶的聚-L-赖氨酸（聚LL）复合时，其体内抗肿瘤活性增强。MY-1与聚LL/CMC的复合物在低剂量的MY-1时即可在体内诱导干扰素，而单独的MY-1则不诱导干扰素。对于与2型豚鼠同基因的10号线肝癌（L10），已证明重复瘤内注射该复合物可导致肿瘤生长延迟，并使接种L10肿瘤的动物完全治愈。用相同量的单独的MY-1或聚LL/CMC对动物进行类似处理对肿瘤生长几乎没有治疗效果。
