Davison Andrew J, Cunningham Charles, Sauerbier Walter, McKinnell Robert G
MRC Virology Unit, Church Street, Glasgow G11 5JR, UK.
Beethoven Strasse 35, 35510 Butzbach, Germany.
J Gen Virol. 2006 Dec;87(Pt 12):3509-3514. doi: 10.1099/vir.0.82291-0.
The sequences of two frog herpesviruses, Ranid herpesvirus 1 and Ranid herpesvirus 2, were determined. They are respectively 220 859 and 231 801 bp in size and contain 132 and 147 predicted genes. The genomes are related most closely in the central regions, where 40 genes are conserved convincingly. Nineteen of these genes are also conserved in a fish herpesvirus, Ictalurid herpesvirus 1. The terminal regions of the genomes are largely not conserved and contain many of the 15 families of related genes present in each genome. The frog herpesviruses are unique among sequenced herpesviruses in that the three exons of the gene encoding the putative ATPase subunit of terminase are not specified by the same DNA strand and in that they encode a putative DNA (cytosine-5-)-methyltransferase and have extensively methylated genomes.
测定了两种蛙疱疹病毒——蛙疱疹病毒1和蛙疱疹病毒2的序列。它们的大小分别为220859和231801碱基对，分别包含132个和147个预测基因。基因组在中心区域的相关性最为密切，其中有40个基因被明确保守。这些基因中有19个在一种鱼疱疹病毒——鲶鱼疱疹病毒1中也保守。基因组的末端区域大多不保守，并且包含每个基因组中存在的15个相关基因家族中的许多基因。蛙疱疹病毒在已测序的疱疹病毒中是独特的，因为编码末端酶假定ATP酶亚基的基因的三个外显子并非由同一条DNA链指定，并且它们编码一种假定的DNA（胞嘧啶-5-）-甲基转移酶，并且具有高度甲基化的基因组。
