Schroeder H, Jardine J E, Davis V
Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
J S Afr Vet Assoc. 1994 Dec;65(4):175-8.
An 8-year-old, Maltese-cross bitch presented with chronic neck and back pain and an acute onset of circling, hyperaesthesia and constant crying. Clinical examination revealed temporal muscle atrophy, an abnormal hanging reflex, cervical rigidity and severe hepatomegaly. Ultrasonography of the liver showed several disseminated, poorly demarcated, hypoechoic areas which on fine needle aspirates, contained large numbers of pigmented fungal hyphae. Cerebrospinal fluid examination revealed fungal hyphae and numerous Ehrlichia canis morulae. A diagnosis of systemic phaeohyphomycosis secondary to ehrlichiosis was proposed. Treatment was unsuccessful and the dog was euthanased. At necropsy, multiple yellowish-green to black, necro-granulomatous foci were found throughout the liver parenchyma and similar foci were present in the spleen, renal cortices and adrenal glands. Irregular, multifocal, grey to black foci of malacia were present in both the grey and the white matter of the brain. On histopathological examination pigmented fungal hyphae were demonstrated in the liver, spleen, kidneys, portal lymph node and adrenals, as well as in the brain. Cultures of various organs yielded a fungal organism identified as Xylohypha bantiana.
一只8岁的马尔济斯犬杂交母犬出现慢性颈部和背部疼痛，并突然出现转圈、感觉过敏和持续哭闹。临床检查发现颞肌萎缩、异常的悬垂反射、颈部僵硬和严重肝肿大。肝脏超声检查显示有几个散在的、边界不清的低回声区，细针穿刺抽吸物中含有大量色素沉着的真菌菌丝。脑脊液检查发现真菌菌丝和大量犬埃立克体桑葚体。提出了由埃立克体病继发的系统性暗色丝孢霉病的诊断。治疗未成功，该犬被安乐死。尸检时，在整个肝实质内发现多个黄绿色至黑色的坏死性肉芽肿病灶，脾脏、肾皮质和肾上腺也有类似病灶。大脑灰质和白质均出现不规则的、多灶性的、灰色至黑色的软化灶。组织病理学检查显示，肝脏、脾脏、肾脏、门静脉淋巴结和肾上腺以及大脑中均有色素沉着的真菌菌丝。各器官培养物培养出一种真菌，鉴定为班替木丝霉菌。
