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本文引用的文献

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Detection of neural activity using phase-sensitive optical low-coherence reflectometry.使用相敏光学低相干反射测量法检测神经活动。
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Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber.使用紧凑型飞秒钕玻璃激光器和非线性光纤的超高分辨率实时光学相干断层扫描成像
Opt Express. 2003 Dec 1;11(24):3290-7. doi: 10.1364/oe.11.003290.
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Optophysiology: depth-resolved probing of retinal physiology with functional ultrahigh-resolution optical coherence tomography.光生理学：利用功能性超高分辨率光学相干断层扫描对视网膜生理学进行深度分辨探测。
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Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media.层流光学层析成像：浑浊介质中毫米级深度分辨成像的演示。
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Functional optical coherence tomography for detecting neural activity through scattering changes.用于通过散射变化检测神经活动的功能性光学相干断层扫描技术。
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Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.大鼠体感皮层中总血红蛋白浓度、氧合作用与神经活动的耦合
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Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation.功能激活期间全脑血红蛋白浓度、氧合和血流的同步成像。
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利用光学相干断层扫描技术对大鼠大脑皮层功能激活进行深度分辨成像。

Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography.

作者信息

Aguirre A D, Chen Y, Fujimoto J G, Ruvinskaya L, Devor A, Boas D A

机构信息

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

出版信息

Opt Lett. 2006 Dec 1;31(23):3459-61. doi: 10.1364/ol.31.003459.

DOI:10.1364/ol.31.003459
PMID:17099749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2293976/
Abstract

Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model.

摘要

在前爪电刺激期间，通过变薄的颅骨同时获取大鼠体感皮层的共配准光学相干断层扫描（OCT）和视频显微镜图像。OCT测量的分数信号变化揭示了与视频显微镜进行的血流动力学信号测量相对应的功能信号时间进程。OCT可以提供功能性神经血管激活的高分辨率横截面图像，并可能为重要的大鼠大脑皮层模型中的基础神经科学研究提供一种新工具。