利用光学相干断层扫描技术对大鼠大脑皮层功能激活进行深度分辨成像。
Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography.
作者信息
Aguirre A D, Chen Y, Fujimoto J G, Ruvinskaya L, Devor A, Boas D A
机构信息
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Opt Lett. 2006 Dec 1;31(23):3459-61. doi: 10.1364/ol.31.003459.
Abstract
Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model.
摘要
在前爪电刺激期间，通过变薄的颅骨同时获取大鼠体感皮层的共配准光学相干断层扫描（OCT）和视频显微镜图像。OCT测量的分数信号变化揭示了与视频显微镜进行的血流动力学信号测量相对应的功能信号时间进程。OCT可以提供功能性神经血管激活的高分辨率横截面图像，并可能为重要的大鼠大脑皮层模型中的基础神经科学研究提供一种新工具。
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