使用紧凑型飞秒钕玻璃激光器和非线性光纤的超高分辨率实时光学相干断层扫描成像

Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber.

作者信息

Bourquin S, Aguirre A, Hartl I, Hsiung P, Ko T, Fujimoto J, Birks T, Wadsworth W, Bünting U, Kopf D

出版信息

Opt Express. 2003 Dec 1;11(24):3290-7. doi: 10.1364/oe.11.003290.

DOI:10.1364/oe.11.003290

PMID:19471457

Abstract

Ultrahigh resolution, real time OCT imaging is demonstrated using a compact femtosecond Nd:Glass laser that is spectrally broadened in a high numerical aperture single mode fiber. A reflective grating phase delay scanner enables broad bandwidth, high-speed group delay scanning. We demonstrate in vivo, ultrahigh resolution, real time OCT imaging at 1 microm center wavelength with <5 microm axial resolution in free space (<4 microm in tissue). The light source is robust, portable, and well suited for in vivo imaging studies.

摘要

使用一种紧凑型飞秒钕玻璃激光器展示了超高分辨率实时光学相干断层扫描（OCT）成像，该激光器在高数值孔径单模光纤中实现了光谱展宽。一种反射光栅相位延迟扫描仪实现了宽带宽、高速群延迟扫描。我们展示了在活体中，以1微米中心波长进行超高分辨率实时OCT成像，在自由空间中的轴向分辨率小于5微米（在组织中小于4微米）。该光源坚固、便携，非常适合活体成像研究。