表面蛋白和外毒素是金黄色葡萄球菌肺炎发病机制所必需的。
Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia.
作者信息
Bubeck Wardenburg Juliane, Patel Ravi J, Schneewind Olaf
机构信息
Department of Microbiology, University of Chicago, 920 E. 58th St., Chicago, IL 60637, USA.
出版信息
Infect Immun. 2007 Feb;75(2):1040-4. doi: 10.1128/IAI.01313-06. Epub 2006 Nov 13.
Abstract
A model of Staphylococcus aureus-induced pneumonia in adult, immunocompetent C57BL/6J mice is described. This model closely mimics the clinical and pathological features of pneumonia in human patients. Using this system, we defined a role for S. aureus strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.
摘要
本文描述了一种在成年、免疫功能正常的C57BL/6J小鼠中建立的金黄色葡萄球菌诱导的肺炎模型。该模型紧密模拟了人类患者肺炎的临床和病理特征。利用这个系统，我们确定了金黄色葡萄球菌纽曼菌株表面蛋白和分泌性外毒素在肺炎相关死亡率中的作用。
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