Grossi Enzo, Groth Nicola, Mosconi Paola, Cerutti Renata, Pace Fabio, Compare Angelo, Apolone Giovanni
Medical Department Bracco SpA, Milan, Italy.
Health Qual Life Outcomes. 2006 Nov 14;4:88. doi: 10.1186/1477-7525-4-88.
The PGWBI is a 22-item health-related Quality of Life (HRQoL) questionnaire developed in US which produces a self-perceived evaluation of psychological well-being expressed by a summary score. The PGWBI has been validated and used in many countries on large samples of the general population and on specific patient groups. Recently a study was carried out in Italy to reduce the number of items of the original questionnaire, yielding the creation of a shorter validated version of the questionnaire (PGWB-S). The purpose of the present paper is to describe the methods adopted and to report and discuss the relevance of results.
Data for this study were collected from 4 different population samples: two general population samples a student and a patient sample. On the basis of the results of the first (development) sample population, six relevant items were identified statistically from the original questionnaire and grouped to assemble a new summary scale. Following the newly created 6-item questionnaire was administered in three independent population samples. Descriptive statistics, correlation coefficients, univariate and multivariate regression analyses were used to compare the performance of the long and short questionnaire, within and between population samples and across relevant subgroups. A further independent sample extracted by an ongoing cancer clinical trial served as final validation step.
Overall, the questionnaires were administered to 1443 subjects. Six items were selected by a step-wise approach to explain 90% of the variance of the summary measure of the original questionnaire. Response rates reached 100%, while missing items were not observed. University students (n = 400) showed the highest mean value of the summary measure (75.3); while the patient sample (n = 28) had the lowest score (71.5). The correlation coefficients between the summary measures and the single items according to the different studies were satisfactory, reaching the highest estimates in the student sample. The internal consistency showed high values of the Cronbach's alpha coefficient (range 0.80-0.92) for all three study samples, coming close to the value of the coefficient established for the original questionnaire (0.94). A cross-validation in an independent sample of 755 cancer patients confirmed the item selection procedure and amount of variance explained by the new shorter questionnaire (ranging from 90. 2 to 95.1 %, across age and sex strata).
The newly identified PGWB-S showed good acceptability and validity for the use in various settings in Italy. The translation of the PGWB-S into different languages, and its use in other linguistic settings will add evidence about its cross-cultural validity.
PGWBI是一份由美国开发的包含22个条目的健康相关生活质量(HRQoL)问卷,通过一个汇总分数得出对心理健康的自我感知评价。PGWBI已在许多国家针对一般人群的大样本和特定患者群体进行了验证和使用。最近在意大利开展了一项研究,以减少原始问卷的条目数量,从而产生了一个经过验证的较短版本问卷(PGWB-S)。本文的目的是描述所采用的方法,并报告和讨论结果的相关性。
本研究的数据收集自4个不同的人群样本:两个一般人群样本、一个学生样本和一个患者样本。根据第一个(开发)样本群体的结果,从原始问卷中通过统计学方法确定了6个相关条目,并将其分组以构建一个新的汇总量表。随后,在三个独立的人群样本中发放新创建的6条目问卷。使用描述性统计、相关系数、单变量和多变量回归分析来比较长问卷和短问卷在人群样本内部和之间以及相关亚组中的表现。从正在进行的癌症临床试验中提取的另一个独立样本作为最终验证步骤。
总体而言,共向1443名受试者发放了问卷。通过逐步方法选择了6个条目,以解释原始问卷汇总测量中90%的方差。回复率达到100%,未观察到缺失条目。大学生(n = 400)的汇总测量平均值最高(75.3);而患者样本(n = 28)得分最低(71.5)。根据不同研究,汇总测量与单个条目的相关系数令人满意,在学生样本中达到最高估计值。所有三个研究样本的内部一致性显示Cronbach's alpha系数值较高(范围为0.80 - 0.92),接近为原始问卷确定的系数值(0.94)。在755名癌症患者的独立样本中进行的交叉验证证实了条目选择程序以及新的较短问卷所解释的方差量(在年龄和性别分层中范围为90.2%至95.1%)。
新确定的PGWB-S在意大利的各种环境中使用时显示出良好的可接受性和有效性。将PGWB-S翻译成不同语言并在其他语言环境中使用,将为其跨文化有效性提供更多证据。