Bajénoff Marc, Egen Jackson G, Koo Lily Y, Laugier Jean Pierre, Brau Frédéric, Glaichenhaus Nicolas, Germain Ronald N
Lymphocyte Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.
Immunity. 2006 Dec;25(6):989-1001. doi: 10.1016/j.immuni.2006.10.011. Epub 2006 Nov 16.
After entry into lymph nodes (LNs), B cells migrate to follicles, whereas T cells remain in the paracortex, with each lymphocyte type showing apparently random migration within these distinct areas. Other than chemokines, the factors contributing to this spatial segregation and to the observed patterns of lymphocyte movement are poorly characterized. By combining confocal, electron, and intravital microscopy, we showed that the fibroblastic reticular cell network regulated naive T cell access to the paracortex and also supported and defined the limits of T cell movement within this domain, whereas a distinct follicular dendritic cell network similarly served as the substratum for movement of follicular B cells. These results highlight the central role of stromal microanatomy in orchestrating cell migration within the LN.
进入淋巴结（LN）后，B细胞迁移至滤泡，而T细胞则留在副皮质区，每种淋巴细胞类型在这些不同区域内均表现出明显的随机迁移。除趋化因子外，导致这种空间分隔以及所观察到的淋巴细胞运动模式的因素目前了解甚少。通过结合共聚焦显微镜、电子显微镜和活体显微镜，我们发现成纤维网状细胞网络调节幼稚T细胞进入副皮质区，同时也支持并界定了T细胞在该区域内的运动范围，而独特的滤泡树突状细胞网络同样为滤泡B细胞的运动提供了基质。这些结果突出了基质微观解剖结构在协调淋巴结内细胞迁移中的核心作用。
