Lemos Marivane, de Barros Muriel Primon, Sousa João Paulo Barreto, da Silva Filho Ademar Alves, Bastos Jairo Kenupp, de Andrade Sérgio Faloni
Núcleo de Ciência e Tecnologia, Area de Ciências Biológicas e da Saúde, Universidade do Oeste de Santa Catarina, Campus de Videira, Rua Paese, 198, Bairro das Torres, Videira-SC, 89560-000, SC, Brazil.
J Pharm Pharmacol. 2007 Apr;59(4):603-8. doi: 10.1211/jpp.59.4.0017.
Baccharis dracunculifolia is the most important botanical source of Southeastern Brazilian propolis, known as green propolis for its colour. In a previous study, we described the gastric protective effect of the hydroalcoholic extract of Brazilian green propolis. We therefore wanted to investigate the possibility of using B. dracunculifolia extract for antiulcer treatment. This study was undertaken to evaluate the anti-ulcerogenic property of hydroalcoholic extract of B. dracunculifolia aerial parts. The HPLC analysis of the chemical composition of B. dracunculifolia extract used in this study revealed the presence mainly of cinnamic acid derivates and flavonoids. Doses of 50, 250 and 500 mg/kg of B. dracunculifolia crude extract and positive controls (omeprazole or cimetidine) significantly diminished the lesion index, the total lesion area and the percentage of lesion compared with negative control groups. The percentage of ulcer inhibition was significantly higher in groups treated with B. dracunculifolia, cimetidine or omeprazole, with all protocols used, compared with negative control groups. Regarding the model of gastric secretion, reductions in the volume of gastric juice and total acidity were observed, as well as an increase in the gastric pH. These results were similar to results from studies carried out with green propolis extract. Although more investigations are required, our results suggest that B. dracunculifolia has potential to be used as a phytotherapic preparation for the treatment of gastric ulcer.
巴西酒神菊是巴西东南部蜂胶最重要的植物来源，因其颜色而被称为绿蜂胶。在之前的一项研究中，我们描述了巴西绿蜂胶水醇提取物的胃保护作用。因此，我们想研究使用巴西酒神菊提取物进行抗溃疡治疗的可能性。本研究旨在评估巴西酒神菊地上部分水醇提取物的抗溃疡特性。对本研究中使用的巴西酒神菊提取物的化学成分进行的高效液相色谱分析表明，其主要成分是肉桂酸衍生物和黄酮类化合物。与阴性对照组相比，50、250和500mg/kg剂量的巴西酒神菊粗提取物以及阳性对照（奥美拉唑或西咪替丁）显著降低了损伤指数、总损伤面积和损伤百分比。与阴性对照组相比，在所有使用的方案中，用巴西酒神菊、西咪替丁或奥美拉唑治疗的组的溃疡抑制百分比显著更高。关于胃分泌模型，观察到胃液体积和总酸度降低，以及胃pH值升高。这些结果与用绿蜂胶提取物进行的研究结果相似。尽管还需要更多的研究，但我们的结果表明，巴西酒神菊有潜力用作治疗胃溃疡的植物疗法制剂。
