Monsalve María, Borniquel Sara, Valle Inmaculada, Lamas Santiago
Centro de Investigaciones Biológicas (Consejo Superior de Investigaciones Científicas), Ramiro de Maeztu 9, 28040, Madrid, Spain.
Front Biosci. 2007 Jan 1;12:1131-53. doi: 10.2741/2132.
The integrity of mitochondrial function is fundamental to cell life. The cell demands for mitochondria and their complex integration into cell biology, extends far beyond the provision of ATP. It follows that disturbances of mitochondrial function lead to disruption of cell function, expressed as disease or even death. Mitochondria are major producers of free radical species and also possibly of nitric oxide, and are, at the same time, major targets for oxidative damage. In this review we consider recent developments in our knowledge of how the mitochondrial production of reactive oxygen species (ROS) plays a critical role in several major human pathologies. We will also consider recent advances in our understanding of the molecular mechanisms involved in mitochondrial ROS detoxification.
线粒体功能的完整性是细胞生命的基础。细胞对线粒体的需求以及它们与细胞生物学的复杂整合，远远超出了提供ATP的范畴。因此，线粒体功能紊乱会导致细胞功能破坏，表现为疾病甚至死亡。线粒体是自由基以及可能还有一氧化氮的主要产生者，同时也是氧化损伤的主要靶点。在本综述中，我们探讨了关于线粒体活性氧（ROS）生成如何在几种主要人类疾病中起关键作用的最新研究进展。我们还将探讨在理解线粒体ROS解毒所涉及的分子机制方面的最新进展。
