Biagini G, Pugnaloni A, Damadei A, Bertani A, Belligolli A, Bicchiega V, Muzzarelli R
Facoltà di Medicina e Chirurgia, Università di Ancona, Italy.
Biomaterials. 1991 Apr;12(3):287-91. doi: 10.1016/0142-9612(91)90036-a.
Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.
将涂有N-羧丁基壳聚糖的扩张器植入兔背部皮肤的手术伤口中，并通过扫描电子显微镜和透射电子显微镜研究包膜组织的形成。在包膜组织形成过程中，N-羧丁基壳聚糖有利于并增强组织的正确增殖和组织化，而不是维持导致瘢痕形成的反应过程。N-羧丁基壳聚糖在生理上刺激组织修复过程并有利于血管生成，同时在一定程度上抑制纤维生成。预计可应用于伤口治疗和整形手术。
