Muzzarelli R, Baldassarre V, Conti F, Ferrara P, Biagini G, Gazzanelli G, Vasi V
Chimica e P. Biochimica, Facolta di Medicina, Università di Ancona, Italy.
Biomaterials. 1988 May;9(3):247-52. doi: 10.1016/0142-9612(88)90092-0.
Reparative processes are reconstructive phenomena in which cellular elements and extracellular matrix glycoproteins interact to build the injured tissue. Biomaterials can be used to improve or stimulate reconstruction. In the present experimental investigation, tissue repair induced by chitosan, an 86.8% deacetylated poly(GlcNAc), was monitored by morphological analysis. To evaluate its biological role, chitosan was positioned in contact with dura mater or was used as a dura mater substitute. This polysaccharide, having structural characteristics similar to glycosaminoglycans, seems to mimic their functional behaviour. The inductive and stimulatory activity of chitosan on connective tissue-rebuilding is clearly demonstrated, and it is suggested that chitosan could be considered a primer on which a normal tissue architecture is organized.
修复过程是一种重建现象，其中细胞成分与细胞外基质糖蛋白相互作用以构建受损组织。生物材料可用于改善或刺激重建。在本实验研究中，通过形态学分析监测了由86.8%脱乙酰化的聚（葡萄糖胺）壳聚糖诱导的组织修复。为了评估其生物学作用，将壳聚糖置于与硬脑膜接触的位置或用作硬脑膜替代物。这种多糖具有与糖胺聚糖相似的结构特征，似乎模仿了它们的功能行为。壳聚糖对结缔组织重建的诱导和刺激活性得到了明确证明，并且有人提出壳聚糖可以被视为构建正常组织结构的引物。
