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撒丁岛患者中克罗恩病、副结核分枝杆菌感染与SLC11A1基因多态性之间的关系

Relationship between Crohn's disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients.

作者信息

Sechi Leonardo-A, Gazouli Maria, Sieswerda Lee-E, Molicotti Paola, Ahmed Niyaz, Ikonomopoulos John, Scanu Antonio-M, Paccagnini Daniela, Zanetti Stefania

机构信息

Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Università degli studi di Sassari, Viale S. Pietro 43/B, 07100 Sassari, Italy.

出版信息

World J Gastroenterol. 2006 Nov 28;12(44):7161-4. doi: 10.3748/wjg.v12.i44.7161.

Abstract

AIM

To study the association between Crohn's disease (CD), Mycobacterium avium subspecies paratuberculosis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sardinian patients with CD and controls.

METHODS

Thirty-seven CD patients and 34 controls with no inflammatory bowel disease (IBD) were recruited at the University of Sassari after giving written consent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M. paratuberculosis was identified by IS900 PCR and sequencing. Logistic regression was used to calculate odds ratios (OR) for the associations among CD, presence of MAP, and 6 loci described above.

RESULTS

For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated with both NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated.

CONCLUSION

Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of genetic, infectious, and immunologic factors in the etiology of CD is complex.

摘要

目的

通过研究自然抗性相关巨噬细胞蛋白1(NRAMP1)基因多态性(现称SLC11A1)在撒丁岛克罗恩病(CD)患者及对照中的作用,探讨CD、副结核分枝杆菌(MAP)与遗传因素之间的关联。

方法

在获得书面同意后,于萨萨里大学招募了37例CD患者和34例无炎症性肠病(IBD)的对照。检测先前报道的与IBD最显著相关的6种SCL11A1多态性。通过IS900 PCR和测序鉴定副结核分枝杆菌。采用逻辑回归计算CD、MAP存在与上述6个位点之间关联的比值比(OR)。

结果

首次观察到NRAMP1基因座823C/T处的多态性与CD之间存在强关联。虽然CD与NRAMP1和MAP均密切相关,但NRAMP1多态性与MAP本身并无相关性。

结论

结合先前关于NOD2/CARD15基因的研究工作,显然CD病因中遗传、感染和免疫因素之间的相互作用较为复杂。

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