在甲状腺病变细针穿刺细胞学检查过程中我们应该应用抽吸吗？一项系统评价和Meta分析。
Should we apply suction during fine needle cytology of thyroid lesions? A systematic review and meta-analysis.
作者信息
Pothier David D, Narula A A
机构信息
Department of Otolaryngology, Gloucester Royal Hospital, Gloucester, UK.
出版信息
Ann R Coll Surg Engl. 2006 Nov;88(7):643-5. doi: 10.1308/003588406X149147.
INTRODUCTION
Fine needle aspiration cytology (FNAC) is a well-established investigation in thyroid disease. Fine needle sampling without aspiration (FNS) is less commonly used but often easier to perform. Both methods have advantages and disadvantages but, as yet, there is no agreement on which method produces better specimens for cytological diagnosis.
MATERIALS AND METHODS
We undertook a review of the literature and performed a meta-analysis of the results of four cross-over trials.
RESULTS
The resulting odds ratio favoured FNS (OR = 0.99; 95% CI 0.88-1.11) but was not statistically significant. A fifth paper not included in the meta-analysis reported results in favour of FNS (P = 0.003).
CONCLUSIONS
There is no evidence from the meta-analysis that one method is superior to the other; however, taking into consideration all available evidence, it seems that FNS may be easier to perform and may produce better samples.
引言
细针穿刺细胞学检查（FNAC）是甲状腺疾病一种成熟的检查方法。无抽吸细针采样（FNS）较少使用，但通常操作起来更容易。两种方法都有优缺点，但目前对于哪种方法能产生更好的标本用于细胞学诊断尚无定论。
材料与方法
我们对文献进行了综述，并对四项交叉试验的结果进行了荟萃分析。
结果
得出的优势比支持FNS（OR = 0.99；95% CI 0.88 - 1.11），但无统计学意义。荟萃分析未纳入的第五篇论文报告的结果支持FNS（P = 0.003）。
结论
荟萃分析没有证据表明一种方法优于另一种方法；然而，考虑到所有现有证据，似乎FNS可能操作起来更容易，并且可能产生更好的样本。
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