Adam Fabiola M S, Nara Mario G B, Adam John M F
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hasanuddin University, Makasar, Indonesia.
Acta Med Indones. 2006 Oct-Dec;38(4):179-84.
in this study we report the relationship between fasting plasma insulin, C-reactive protein, adiponectin levels and the components of metabolic syndrome.
for the diagnosis of metabolic syndrome we used the modified NCEP ATP criteria for Asian people. Complete routine physical examinations were performed to all subjects including blood pressure, waist circumference. After 12-hours fasting, blood sample was taken for fasting plasma glucose, fasting insulin, and lipid profiles. Fasting insulin was determined by RIA, adiponectin by ELISA, and hs-CRP by sensitive immunometric assay. According to NCEP ATP III, the metabolic syndrome consists of five components. Subjects fulfilling the studied criteria were divided into five groups according to the component/components they had.
during the study, 118 adult individuals can be covered, including 88 patients (68,8%) with metabolic syndrome. They consist of 19 subjects who had only 1 component, 21 subjects had 2 components, 31 subjects with 3 components, 34 subjects with 4 components, and 23 subjects had 5 component. All subjects were overweight/obese (BMI > 23 kg/m), but patients with metabolic syndrome were significantly more obese compared to the non-metabolic syndrome (p < 0.05). There was no significant difference in age among all individuals. Fasting insulin, hs-CRP levels is increasing with the increasing number of components of metabolic syndrome, being higher among those with 3-5 components, while adiponectin is decreasing with the number of the components. Fasting insulin 3,5+1,1 uU/ml, 3,6+1,4 uU/ml, 5,9+1,8 uU/ml, 7,8+2,1 uU/ml, 7,9+2,3 uU/ml respectively, hs-CRP 2,8+1,2 mg/L, 5.6+3.4 mg/L, 7.4+4.4 mg/L, 9.0+4.7 mg/L, 9.5+3,9 mg/L, and adiponectin 9.1+3.5 ng/ml, 8.6+1.6 ng/ml, 3.4+1.2 ng/ml, 3.2+1.3 ng/ml, 2.8+0.9 ng/ml in 3,4,5 components respectively.
there is a relationship between the number of components of metabolic syndrome and the increasing levels of fasting insulin, and hs-CRP, and low levels of adiponectin. These may explain in part the risk of cardiovascular events among individuals with metabolic syndrome.
在本研究中，我们报告空腹血浆胰岛素、C反应蛋白、脂联素水平与代谢综合征各组分之间的关系。
对于代谢综合征的诊断，我们采用针对亚洲人群修改后的美国国家胆固醇教育计划成人治疗组第三次报告（NCEP ATP）标准。对所有受试者进行全面的常规体格检查，包括血压、腰围。禁食12小时后，采集血样检测空腹血糖、空腹胰岛素和血脂谱。空腹胰岛素采用放射免疫分析法（RIA）测定，脂联素采用酶联免疫吸附测定法（ELISA）测定，高敏C反应蛋白（hs-CRP）采用敏感免疫比浊法测定。根据NCEP ATP III，代谢综合征由五个组分组成。符合研究标准的受试者根据其具有的一个或多个组分分为五组。
在研究期间，纳入118名成年个体，其中88例（68.8%）患有代谢综合征。他们包括19名仅有一种组分的受试者，21名有两种组分的受试者，31名有三种组分的受试者，34名有四种组分的受试者，以及23名有五种组分的受试者。所有受试者均超重/肥胖（体重指数>23kg/m²），但与非代谢综合征患者相比，代谢综合征患者明显更肥胖（p<0.05）。所有个体之间年龄无显著差异。空腹胰岛素、hs-CRP水平随着代谢综合征组分数量的增加而升高，在具有3 - 5种组分的受试者中更高，而脂联素则随着组分数量的增加而降低。在分别具有3、4、5种组分的受试者中，空腹胰岛素水平分别为3.5 + 1.1 uU/ml、3.6 + 1.4 uU/ml、5.9 + 1.8 uU/ml、7.8 + 2.1 uU/ml、7.9 + 2.3 uU/ml，hs-CRP水平分别为2.8 + 1.2 mg/L、5.6 + 3.4 mg/L、7.4 + 4.4 mg/L、9.0 + 4.7 mg/L、9.5 + 3.9 mg/L，脂联素水平分别为9.1 + 3.5 ng/ml、8.6 + 1.6 ng/ml、3.4 + 1.2 ng/ml、3.2 + 1.3 ng/ml、2.8 + 0.9 ng/ml。
代谢综合征的组分数量与空腹胰岛素水平升高、hs-CRP水平升高以及脂联素水平降低之间存在关联。这些可能部分解释了代谢综合征患者发生心血管事件的风险。
