Stjärne P, Lacroix J S, Anggård A, Lundberg J M
Department of Oto-Rhino-Laryngology, Karolinska Hospital, Stockholm, Sweden.
Acta Physiol Scand. 1991 Mar;141(3):335-42. doi: 10.1111/j.1748-1716.1991.tb09089.x.
The vascular effects of local infusion of capsaicin, substance P (SP), calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) were monitored in an experimental model on the pig nasal mucosa. Arterial, venous and superficial mucosal blood flow (laser-Doppler flowmetry) as well as mucosal volume, reflecting changes in capacitance vessels were studied in parallel. All substances induced concentration dependent increases in the parameters studied with the exception of the decrease in the superficial mucosal flow induced by vasoactive intestinal polypeptide. This latter finding was interpreted as a stealing phenomenon and suggests that vasoactive intestinal polypeptide mainly exerts its vasodilatory effect in the deeper glandular layers of the nasal mucosa. The vasodilatory effect of capsaicin, except the laser-Doppler signal, was markedly reduced by pretreatment with a combination of the ganglionic blocking agent chlorisondamine and atropine implying that capsaicin evokes a central reflex with a final parasympathetic pathway and release of agents like vasoactive intestinal polypeptide. The remaining capsaicin response may depend on a local effect with axon reflexes and the release of sensory neuropeptides with actions on superficial mucosal blood flow.
在猪鼻黏膜实验模型中监测了局部注入辣椒素、P物质（SP）、降钙素基因相关肽（CGRP）和血管活性肠肽（VIP）的血管效应。同时研究了动脉、静脉和浅表黏膜血流（激光多普勒血流仪）以及反映容量血管变化的黏膜体积。除血管活性肠肽引起浅表黏膜血流减少外，所有物质均引起所研究参数的浓度依赖性增加。后一发现被解释为一种窃血现象，表明血管活性肠肽主要在鼻黏膜较深的腺层发挥其血管舒张作用。除激光多普勒信号外，辣椒素的血管舒张作用在预先用神经节阻断剂氯异吲哚铵和阿托品联合处理后明显减弱，这意味着辣椒素引发了一种中枢反射，其最终通过副交感神经通路并释放血管活性肠肽等物质。剩余的辣椒素反应可能取决于轴突反射的局部效应以及感觉神经肽的释放，这些神经肽对浅表黏膜血流有作用。
